Document Detail


Continuous monitoring of liver oxygenation with near infrared spectroscopy during naso-gastric tube feeding in neonates.
MedLine Citation:
PMID:  10846757     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Near infrared spectroscopy (NIRS) is a non-invasive method of estimating the haemoglobin concentration changes in certain tissues. It is frequently used to monitor oxygenation of the brain in neonates. At present it is not clear whether near infrared spectroscopy of other organs (e.g. the liver as a corresponding site in the splanchnic region, which reacts very sensitively to haemodynamic instability) provides reliable values on their tissue oxygenation. The aim of the study was to test near infrared spectroscopy by measuring known physiologic changes in tissue oxygenation of the liver in newborn infants during and after feeding via a naso-gastric tube. The test-retest variability of such measurements was also determined. On 28 occasions in 25 infants we measured the tissue oxygenation index (TOI) of the liver and the brain continuously before, during and 30 minutes after feeding via a gastric tube. Simultaneously we measured arterial oxygen saturation (SaO2), heart rate (HR) and mean arterial blood pressure (MAP). In 10 other newborn infants we performed a test-retest analysis of the liver tissue oxygenation index to estimate the variability in repeated intra-individual measurements. The tissue oxygenation index of the liver increased significantly from 56.7 +/- 7.5% before to 60.3 +/- 5.6% after feeding (p < 0.005), and remained unchanged for the next 30 minutes. The tissue oxygenation index of the brain (62.1 +/- 9.7%), SaO2 (94.4 +/- 7.1%), heart rate (145 +/- 17.3 min-1) and mean arterial blood pressure (52.8 +/- 10.2 mm Hg) did not change significantly. The test-retest variability for intra-individual measurements was 2.7 +/- 2.1%. After bolus feeding the tissue oxygenation index of the liver increased as expected. This indicates that near infrared spectroscopy is suitable for monitoring changes in tissue oxygenation of the liver in newborn infants.
Authors:
J Teller; K Schwendener; M Wolf; M Keel; H U Bucher; S Fanconi; O Baenziger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Schweizerische medizinische Wochenschrift     Volume:  130     ISSN:  0036-7672     ISO Abbreviation:  Schweiz Med Wochenschr     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-06-30     Completed Date:  2000-06-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404401     Medline TA:  Schweiz Med Wochenschr     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  652-6     Citation Subset:  IM    
Affiliation:
University Children's Hospital, Zurich.
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure
Enteral Nutrition*
Female
Gestational Age
Heart Rate
Humans
Infant, Newborn
Infant, Premature
Intubation, Gastrointestinal*
Liver / blood supply*,  metabolism*
Male
Monitoring, Physiologic
Oxygen / blood*
Oxygen Consumption
Reproducibility of Results
Spectrophotometry, Infrared / methods
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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