Document Detail


Continuous monitoring of energy metabolites using microdialysis during myocardial ischaemia in the pig.
MedLine Citation:
PMID:  7789376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A diagonal branch of the left anterior descending artery was occluded for 80 min. One microdialysis probe was inserted in the ischaemic area and two in the non-ischaemic areas. In six animals radiolabelled microspheres were injected before and during ischaemia and after reperfusion to monitor flow. Arterial and pulmonary artery pressures, pulmonary capillary wedge pressure and cardiac output were followed-up. Radiolabelled microsphere distribution confirmed the reduction of myocardial blood flow during coronary artery occlusion, with flow returning to normal values upon reperfusion. Rate pressure product as an index of heart work was stable throughout the 80 min ischaemic period, but increased at reperfusion. Dialysates from non-ischaemic tissue showed stable baseline values. In ischaemic tissue, lactate increased by 300% and pyruvate levels decreased by 50% within 15 min. Adenosine increased rapidly five-fold, but started to decline after 15 min of ischaemia. Inosine showed a slower but a marked 20-fold increase, decreasing at the end of the ischaemic period. Hypoxanthine increased five-fold during the first 30 min. Finally, guanosine showed a slow increase to about four times above basic values. Microdialysis was an excellent tool for the continuous monitoring of myocardial metabolites during ischaemia. Adenosine appeared to be a more sensitive marker of early ischaemia than lactate, although interestingly, adenosine levels had decreased already after 15 min, most probably due to intracellular accumulation of protons and Pi.
Authors:
G Wikström; G Ronquist; S Nilsson; E Maripu; A Waldenström
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European heart journal     Volume:  16     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-07-27     Completed Date:  1995-07-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  339-47     Citation Subset:  IM    
Affiliation:
Department of Cardiology, University Hospital, Uppsala, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adenosine / metabolism
Animals
Energy Metabolism / physiology*
Female
Guanosine / metabolism
Hemodynamics / physiology
Hypoxanthine
Hypoxanthines / metabolism
Inosine / metabolism
Lactates / metabolism
Lactic Acid
Male
Microdialysis / instrumentation*
Monitoring, Physiologic / instrumentation*
Myocardial Infarction / physiopathology
Myocardial Ischemia / physiopathology*
Myocardial Reperfusion Injury / physiopathology
Myocardium / metabolism*
Pyruvates / metabolism
Pyruvic Acid
Swine
Chemical
Reg. No./Substance:
0/Hypoxanthines; 0/Lactates; 0/Pyruvates; 118-00-3/Guanosine; 127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid; 58-61-7/Adenosine; 58-63-9/Inosine; 68-94-0/Hypoxanthine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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