Document Detail

Continuous measurement of cerebral cortical blood flow by laser-Doppler flowmetry in a rat stroke model.
MedLine Citation:
PMID:  2674168     Owner:  NLM     Status:  MEDLINE    
Laser-Doppler flowmetry (LDF), a new method allowing instantaneous, continuous, and noninvasive measurements of microcirculatory blood flow in a small tissue sample, was evaluated for its accuracy in monitoring regional cerebral blood flow (rCBF) in the cortical microcirculation after focal cerebral ischemia. Wistar and spontaneously hypertensive rats (SHR, n = 19) were subjected to permanent occlusion of the middle cerebral and common carotid arteries. Absolute rCBF in a tissue sample of the ischemic hemisphere was measured autoradiographically with [14C]iodoantipyrine as a tracer and compared to rCBF measured by LDF. Additionally, the percent change in rCBF between baseline and ischemic values was compared for both methods. Absolute rCBF values recorded with LDF correlated poorly (r = 0.54) with [14C]iodoantipyrine measurements. In contrast LDF readings expressed as a percentage of ischemic vs. preocclusion readings (relative LDF readings) correlated very well (r = 0.91) with the percent change in [14C]iodoantipyrine measurements. We conclude that LDF does not provide accurate measurements of absolute rCBF values but this method allows accurate measurements of changes in rCBF due to induction of focal cerebral ischemia.
U Dirnagl; B Kaplan; M Jacewicz; W Pulsinelli
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  9     ISSN:  0271-678X     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-10-19     Completed Date:  1989-10-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  589-96     Citation Subset:  IM    
Department of Neurology, Cornell University Medical College, New York, New York 10021.
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MeSH Terms
Antipyrine / analogs & derivatives,  diagnostic use
Brain Ischemia / physiopathology
Carbon Radioisotopes / diagnostic use
Cerebral Cortex / blood supply
Cerebrovascular Circulation*
Cerebrovascular Disorders / physiopathology*
Lasers / diagnostic use*
Rats, Inbred SHR
Reference Values
Grant Support
Reg. No./Substance:
0/Carbon Radioisotopes; 129-81-7/iodoantipyrine; 60-80-0/Antipyrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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