Document Detail


Continuous measurement of atrial volume with an impedance catheter during positive pressure ventilation and volume expansion.
MedLine Citation:
PMID:  2160739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Right atrial volume (RAV) and other hemodynamic parameters were measured in ten anesthetized swine with an impedance catheter in the right atrium during ventilation and increasing levels of positive end-expiratory pressure (PEEP) to determine the effects of PEEP on right atrial dynamics. RAV and cardiac output (CO) decreased progressively during ventilation with 5, 10 and 15 centimeters of water PEEP, whereas central venous pressure and pulmonary capillary wedge pressure increased. Despite this decrease in RAV, atrial ejection fraction increased significantly and active atrial output (AAO equals stroke volume times heart rate) was maintained. Thus, the decrease in CO resulted from a decrease in the passive component of ventricular filling. Compensatory increases in AAO helped to minimize the fall in CO in some swine (r = 0.73, p less than 0.01). Peripheral adenocorticotropin (ACTH) increased from 14.0 +/- 4.5 picograms per milliliter at zero centimeters of water PEEP to 46.8 +/- 18.3 picograms per milliliter at 10 centimeters of water PEEP (p less than 0.05). Volume expansion that restored CO to control levels despite PEEP led to a significant increase in RAV and in passive ventricular filling, as well as a decrease in ACTH to 11.2 +/- 1.5 picograms per milliliter (p less than 0.05). Changes in the ACTH levels correlated with changes in the RAV (r = 0.58, p less than 0.05), but did not correlate with changes in CO, arterial pressure or central venous pressure. The data herein suggest that the decrease in CO with PEEP results from decreased venous return, RAV and passive ventricular filling, whereas a compensatory increase in right atrial contractility helps to maintain CO. Ventilation with PEEP stimulates hormonal secretion that can be terminated by adequate volume expansion.
Authors:
E J DeMaria; K W Burchard; D E Carlson; D S Gann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Surgery, gynecology & obstetrics     Volume:  170     ISSN:  0039-6087     ISO Abbreviation:  Surg Gynecol Obstet     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-06-25     Completed Date:  1990-06-25     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0101370     Medline TA:  Surg Gynecol Obstet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  501-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, Brown University, Providence, Medical College of Virginia.
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / secretion
Animals
Atrial Function*
Blood Pressure
Blood Volume*
Cardiac Output
Central Venous Pressure
Female
Heart Catheterization / methods*
Monitoring, Physiologic / methods*
Positive-Pressure Respiration*
Pulmonary Wedge Pressure
Swine
Grant Support
ID/Acronym/Agency:
GM-27946/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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