| Continuous measurement of aortic caliber in conscious rats. Effect of acute hypertension. | |
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MedLine Citation:
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PMID: 875466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For continuously measuring the circumference of the aorta in conscious rats for up to 20 days, a new electrolytic strain gauge of high sensitivity and stability was constructed of silicone tubing filled with copper nitrate. The mean systolic and diastolic circumferences measured in 11 nonanesthetized undisturbed rats were 6.557 +/- 0.128 mm and 6.533 +/- 0.128 mm, respectively--the pulse pressure (51 mm Hg) producing an increase of 0.024 mm in aortic size (0.37% increase of the diastolic circumference). The calculated dynamic elastic modulus was 13,908 dynes/cm2. Infusions of blood, angiotensin, and noradrenaline to increase mean aortic pressure acutely by 50 mm Hg caused aortic circumference to increase by 0.59, 0.58, and 0.53%, respectively. Seven rats were subjected to acute hypertension produced by subdiaphragmatic aortic constriction after recording the control measurements. Over the period of study (6 hours) after aortic constriction, mean aortic blood pressure was increased 50 mm Hg from the control of 101 mm Hg. A mean maximal increase of 6% in aortic circumference was seen at 3 hours and a mean minimum of 0.9% at 4 hours, with an average increase of 3% for the entire 6-hour period. These changes in aortic circumference coincide with an upward displacement of about 30% in the range of activation of the aortic baroreceptors. |
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Authors:
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L T Compagno; J V Leite; E M Krieger |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mayo Clinic proceedings. Mayo Clinic Volume: 52 ISSN: 0025-6196 ISO Abbreviation: Mayo Clin. Proc. Publication Date: 1977 Jul |
Date Detail:
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Created Date: 1977-08-12 Completed Date: 1977-08-12 Revised Date: 2007-10-29 |
Medline Journal Info:
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Nlm Unique ID: 0405543 Medline TA: Mayo Clin Proc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 433-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / innervation, pathology*, physiopathology Blood Pressure Consciousness Heart Rate Hypertension / pathology*, physiopathology Male Rats |
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