Document Detail

Continuous low-dose antibiotics and cerclage for recurrent second-trimester pregnancy loss.
MedLine Citation:
PMID:  10804489     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the role of continuous low-dose antibiotics in the prolongation of pregnancy in women at risk for recurrent second-trimester loss. METHODS: Only patients with a history of previous recurrent second-trimester losses associated with failed cervical cerclages were prospectively included in the study. Patients received low-dose antibiotics until delivery. Cerclage was performed at 14-24 weeks' gestation on the basis of transvaginal sonographic findings of cervical funneling. Outcome was evaluated by weeks of pregnancy gained in the current pregnancy as compared to the previous pregnancy. RESULTS: Ten patients were eligible for study after exclusions. All 10 achieved fetal viability. Pregnancy was prolonged by a mean of 13.4 +/- 4.2 weeks beyond the previous pregnancy. This was highly statistically significant (P < .001). CONCLUSION: Continuous low-dose antibiotics prolonged pregnancy in patients with recurrent second-trimester pregnancy losses and prior failed cerclage. Randomized clinical trials are needed to confirm the role of antibiotics in these high-risk pregnancies.
R L Shiffman
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  45     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-07-12     Completed Date:  2000-07-12     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  323-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, New York Methodist Hospital, Brooklyn 11210, USA.
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MeSH Terms
Abortion, Spontaneous / prevention & control*
Anti-Bacterial Agents / administration & dosage*,  therapeutic use
Pregnancy Complications / prevention & control*
Pregnancy Outcome
Pregnancy Trimester, Second
Risk Factors
Uterine Cervical Incompetence / pathology,  surgery*
Reg. No./Substance:
0/Anti-Bacterial Agents
Comment In:
J Reprod Med. 2001 Feb;46(2):147   [PMID:  11255816 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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