| Continuous low-dose antibiotics and cerclage for recurrent second-trimester pregnancy loss. | |
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MedLine Citation:
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PMID: 10804489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the role of continuous low-dose antibiotics in the prolongation of pregnancy in women at risk for recurrent second-trimester loss. METHODS: Only patients with a history of previous recurrent second-trimester losses associated with failed cervical cerclages were prospectively included in the study. Patients received low-dose antibiotics until delivery. Cerclage was performed at 14-24 weeks' gestation on the basis of transvaginal sonographic findings of cervical funneling. Outcome was evaluated by weeks of pregnancy gained in the current pregnancy as compared to the previous pregnancy. RESULTS: Ten patients were eligible for study after exclusions. All 10 achieved fetal viability. Pregnancy was prolonged by a mean of 13.4 +/- 4.2 weeks beyond the previous pregnancy. This was highly statistically significant (P < .001). CONCLUSION: Continuous low-dose antibiotics prolonged pregnancy in patients with recurrent second-trimester pregnancy losses and prior failed cerclage. Randomized clinical trials are needed to confirm the role of antibiotics in these high-risk pregnancies. |
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Authors:
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R L Shiffman |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: The Journal of reproductive medicine Volume: 45 ISSN: 0024-7758 ISO Abbreviation: J Reprod Med Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-07-12 Completed Date: 2000-07-12 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0173343 Medline TA: J Reprod Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 323-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, New York Methodist Hospital, Brooklyn 11210, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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prevention & control* Adult Anti-Bacterial Agents / administration & dosage*, therapeutic use Female Humans Pregnancy Pregnancy Complications / prevention & control* Pregnancy Outcome Pregnancy Trimester, Second Recurrence Risk Factors Sutures Uterine Cervical Incompetence / pathology, surgery* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents |
| Comments/Corrections | |
Comment In:
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J Reprod Med. 2001 Feb;46(2):147
[PMID:
11255816
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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