Document Detail


Continuous low-dose antibiotics and cerclage for recurrent second-trimester pregnancy loss.
MedLine Citation:
PMID:  10804489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the role of continuous low-dose antibiotics in the prolongation of pregnancy in women at risk for recurrent second-trimester loss. METHODS: Only patients with a history of previous recurrent second-trimester losses associated with failed cervical cerclages were prospectively included in the study. Patients received low-dose antibiotics until delivery. Cerclage was performed at 14-24 weeks' gestation on the basis of transvaginal sonographic findings of cervical funneling. Outcome was evaluated by weeks of pregnancy gained in the current pregnancy as compared to the previous pregnancy. RESULTS: Ten patients were eligible for study after exclusions. All 10 achieved fetal viability. Pregnancy was prolonged by a mean of 13.4 +/- 4.2 weeks beyond the previous pregnancy. This was highly statistically significant (P < .001). CONCLUSION: Continuous low-dose antibiotics prolonged pregnancy in patients with recurrent second-trimester pregnancy losses and prior failed cerclage. Randomized clinical trials are needed to confirm the role of antibiotics in these high-risk pregnancies.
Authors:
R L Shiffman
Related Documents :
18406509 - Cervical fluid cytokines in pregnant women: relation to vaginal wet mount findings and ...
12053099 - Detection of the cervical gland area in threatened preterm labor using transvaginal son...
18061709 - Cervical preparation for second-trimester surgical abortion prior to 20 weeks of gestat...
9469269 - Chlamydia in pregnancy: a randomized trial of azithromycin and erythromycin.
17674259 - Dynamic cervical length changes: preliminary observations from 30-minute transvaginal u...
17962109 - Successful resection of a cervical pregnancy with original diagnosis of bladder wall in...
18432599 - Reproducibility of sonographic assessment of fetal liver length in diabetic pregnancies.
8240149 - The effect of pregnancy on the epilepsies: a study of 37 pregnancies.
15458739 - The role of matrix degrading enzymes and apoptosis in rupture of membranes.
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  45     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-07-12     Completed Date:  2000-07-12     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  323-6     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, New York Methodist Hospital, Brooklyn 11210, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / prevention & control*
Adult
Anti-Bacterial Agents / administration & dosage*,  therapeutic use
Female
Humans
Pregnancy
Pregnancy Complications / prevention & control*
Pregnancy Outcome
Pregnancy Trimester, Second
Recurrence
Risk Factors
Sutures
Uterine Cervical Incompetence / pathology,  surgery*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents
Comments/Corrections
Comment In:
J Reprod Med. 2001 Feb;46(2):147   [PMID:  11255816 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinical vs. sonographic estimate of birth weight in term parturients. A randomized clinical trial.
Next Document:  Subcutaneous drain vs. suture in obese women undergoing cesarean delivery. A prospective, randomized...