Document Detail


Continuous lidocaine infusion for the relief of refractory malignant pain in a terminally ill pediatric cancer patient.
MedLine Citation:
PMID:  12368697     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite aggressive pain management with opiates, debilitating pain still occurs in a subset of children with terminal cancer. A 5-year-old girl with metastatic retinoblastoma, profound opiate tolerance, and refractory pain was treated. Continuous lidocaine infusion was initiated at a dose of 35 microg/kg per minute and increased over 4 days to 50 microg/kg per minute, at which point the patient was discharged for continued end-of-life comfort care. The patient had excellent pain relief without the associated lethargy of high-dose opiates. No complicating neuroexcitatory symptoms or cardiac conduction abnormalities were experienced. Intravenous lidocaine may be an effective alternative to opioids in the treatment of refractory malignant pain in the pediatric patient with terminal cancer.
Authors:
Gita V Massey; Sheila Pedigo; Nancy L Dunn; Neil J Grossman; E Clifton Russell
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  24     ISSN:  1077-4114     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-07     Completed Date:  2002-11-07     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  566-8     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Division of Hematology/Oncology, Children's Medical Center, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA. gvmassey@hsc.vcu.edu
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MeSH Terms
Descriptor/Qualifier:
Analgesics, Opioid / administration & dosage,  therapeutic use
Child, Preschool
Female
Humans
Injections, Spinal
Lidocaine / administration & dosage*,  therapeutic use*
Neoplasm Metastasis
Pain / complications*,  drug therapy*
Palliative Care / methods*
Quality of Life
Retinoblastoma / complications*,  drug therapy,  mortality
Chemical
Reg. No./Substance:
0/Analgesics, Opioid; 137-58-6/Lidocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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