Document Detail

Continuous left ventricular ejection fraction monitoring by aortic pressure waveform analysis.
MedLine Citation:
PMID:  19308732     Owner:  NLM     Status:  MEDLINE    
We developed a technique to monitor left ventricular ejection fraction (EF) by model-based analysis of the aortic pressure waveform. First, the aortic pressure waveform is represented with a lumped parameter circulatory model. Then, the model is fitted to each beat of the waveform to estimate its lumped parameters to within a constant scale factor equal to the arterial compliance (C (a)). Finally, the proportional parameter estimates are utilized to compute beat-to-beat absolute EF by cancelation of the C (a) scale factor. In this way, in contrast to conventional imaging, EF may be continuously monitored without any ventricular geometry assumptions. Moreover, with the proportional parameter estimates, relative changes in beat-to-beat left ventricular end-diastolic volume (EDV), cardiac output (CO), and maximum left ventricular elastance (E (max)) may also be monitored. To evaluate the technique, we measured aortic pressure waveforms, reference EF and EDV via standard echocardiography, and other cardiovascular variables from six dogs during various pharmacological influences and total intravascular volume changes. Our results showed overall EF and calibrated EDV root-mean-squared-errors of 5.6% and 4.1 mL, and reliable estimation of relative E (max) and beat-to-beat CO changes. These results demonstrate, perhaps for the first time, the feasibility of estimating EF from only a blood pressure waveform.
Gokul Swamy; Jacob Kuiper; Madhu S R Gudur; N Bari Olivier; Ramakrishna Mukkamala
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-03-24
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  37     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-05     Completed Date:  2009-06-18     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1055-68     Citation Subset:  IM    
Department of Electrical and Computer Engineering, Michigan State University, 2120 Engineering Building, East Lansing, MI 48824, USA.
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MeSH Terms
Aorta, Thoracic / physiology*
Aortic Valve / physiopathology*
Blood Pressure Determination / methods*
Cardiac Output / physiology
Cardiovascular Agents / pharmacology
Dobutamine / pharmacology
Elasticity Imaging Techniques
Models, Cardiovascular*
Nitroprusside / pharmacology
Phenylephrine / pharmacology
Propanolamines / pharmacology
Stroke Volume / physiology*
Ventricular Function, Left / physiology*
Verapamil / pharmacology
Reg. No./Substance:
0/Cardiovascular Agents; 0/Propanolamines; 15078-28-1/Nitroprusside; 34368-04-2/Dobutamine; 52-53-9/Verapamil; 59-42-7/Phenylephrine; MDY902UXSR/esmolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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