| Continuous intravenous infusion of elastase in normal and agranulocytic minipigs--effects on the lungs and the blood coagulation system. | |
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MedLine Citation:
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PMID: 3024280 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to investigate the acute effects on lung morphology, lung function, hemodynamic and blood coagulation system, elastase (330 units (U) kg-1 h-1) was continuously infused into 16 anesthetized and mechanically ventilated minipigs. Elastase infusion induced a disturbance of blood coagulation leading to hypocoagulability, a pulmonary leukostasis, interstitial edema, a progressive respiratory failure with prompt increase in pulmonary vascular resistance, decrease in systemic vascular resistance, increased venous admixture, and increased dead space ventilation. Agranulocytosis prevented interstitial edema but not disturbances in pulmonary or hemodynamic function or hypocoagulability. The results clearly indicate that elastase may be involved in the pathophysiology of acute lung failure and defects in the blood coagulation system. |
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Authors:
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T Stokke; H Burchardi; I Hensel; H Köstering; T Käthner; G Rahlf |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Resuscitation Volume: 14 ISSN: 0300-9572 ISO Abbreviation: Resuscitation Publication Date: 1986 Sep |
Date Detail:
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Created Date: 1987-01-06 Completed Date: 1987-01-06 Revised Date: 2009-08-25 |
Medline Journal Info:
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Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: IRELAND |
Other Details:
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Languages: eng Pagination: 61-79 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Agranulocytosis
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physiopathology* Animals Blood Coagulation / drug effects* Hemodynamics Lung / drug effects*, physiopathology Pancreatic Elastase / toxicity* Pulmonary Gas Exchange Respiratory Distress Syndrome, Adult / etiology, physiopathology Swine Swine, Miniature |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.36/Pancreatic Elastase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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