| Continuous intravenous infusion of TRH-T: clinical, cardiovascular and endocrinological effects. | |
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MedLine Citation:
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PMID: 1792854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seven patients, six suffering from amyotrophic lateral sclerosis (ALS) and one from Friedreich ataxia, were treated with a placebo i.v. infusion during the first day and with TRH-T i.v. infusion at a rate of 2 mg/h for 8 h daily (total daily dosage 16 mg) on the 2 consecutive days. Continuous blood pressure (BP) and EKG monitorings were performed during 3 days infusion. Blood samples were collected for endocrinological evaluations. The neurological evaluation after acute TRH-T treatment showed an objective improvement in 3 of the 8. We found significantly higher values of systolic (max. difference of 10.1 mm Hg) and diastolic (max. difference of 8.8 mm Hg) BP than during placebo, beginning from the 5th h of the infusion (p less than 0.05). A trend in progressive increase of the heart rate (HR) reached statistical significance (p less than 0.01) at the 8th h of the second TRH-T infusion. The cardiovascular changes during the i.v. continuous TRH-T infusions were clinically irrelevant and never required the interruption of the treatment. |
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Authors:
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R Formisano; S Ruggieri; R Cerbo; F Lucarelli; G De Vuono; M Parmegiani; A Agnoli; A Attanasio; A Capria; C G Piccolo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta neurologica Scandinavica Volume: 84 ISSN: 0001-6314 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 1991 Dec |
Date Detail:
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Created Date: 1992-04-02 Completed Date: 1992-04-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 514-8 Citation Subset: IM |
Affiliation:
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Department of Neurological Science, University La Sapienza, Rome, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amyotrophic Lateral Sclerosis / drug therapy*, physiopathology Electrocardiography, Ambulatory / drug effects Friedreich Ataxia / drug therapy*, physiopathology Humans Infusions, Intravenous Male Middle Aged Neurologic Examination / drug effects Thyroid Hormones / blood Thyrotropin-Releasing Hormone / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Thyroid Hormones; 24305-27-9/Thyrotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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