| Continuous intracranial pressure monitoring and serial electroencephalographic recordings in severely asphyxiated term neonates. | |
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MedLine Citation:
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PMID: 3381777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report our observations from intensive intracranial pressure (ICP) monitoring and serial clinical neurologic and electroencephalographic examinations in ten asphyxiated full-term neonates, of whom five died and at least two survivors had multiple severe neurologic handicaps. Direct measurements of ICP were obtained by a newly developed infant subarachnoid bolt and/or a transfontanelle pressure transducer. Simultaneous ICPs were recorded and correlated when possible. We noted a dependence of transfontanelle ICP values on application technique and force. In infants with no bleeding diathesis, the subarachnoid bolt was safe and no complications were encountered. Only six infants experienced pathologic elevations of ICP following birth asphyxia, and of these infants only two had sustained, marked increases of ICP. We also noted abundant fluctuations of cerebral perfusion pressure (mean arterial blood pressure minus ICP), but the majority of fluctuations were accounted for by mean arterial pressure changes rather than ICP changes. We found no deterioration of clinical neurologic function as measured by serial mental status examinations and electroencephalogram samples at the time the maximum ICP was measured. We also noted very little change in ICP during most electrographic seizures. In these infants ICP did increase after birth but major ICP elevations were uncommon and did not appear to introduce any acute functional neurologic disturbances. Most changes in cerebral perfusion pressure were attributed to blood pressure rather than ICP changes. It appears unlikely that cerebral edema and elevated ICP play a major role in determining neurologic outcome in some asphyxiated term infants. |
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Authors:
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R Clancy; A Legido; R Newell; D Bruce; S Baumgart; W W Fox |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: American journal of diseases of children (1960) Volume: 142 ISSN: 0002-922X ISO Abbreviation: Am. J. Dis. Child. Publication Date: 1988 Jul |
Date Detail:
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Created Date: 1988-07-28 Completed Date: 1988-07-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370471 Medline TA: Am J Dis Child Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 740-7 Citation Subset: AIM; IM |
Affiliation:
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Division of Neurology, Children's Hospital of Philadelphia, PA 19104. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Asphyxia Neonatorum
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complications,
mortality,
physiopathology* Blood Pressure Brain Edema / etiology Electroencephalography* Female Humans Infant, Newborn Intracranial Pressure* Male Monitoring, Physiologic / instrumentation Seizures / etiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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