| Continuous intra-arterial blood pH monitoring by a fiber-optic fluorosensor. | |
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MedLine Citation:
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PMID: 21257367 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Continuous intra-arterial blood pH monitoring is highly desirable in clinical practice. However, devices with appreciable accuracy are still not commercially available to date. In this study we present a fiber-optic fluorosensor that can be used to continuously and accurately measure blood pH changes. The pH sensor is developed based on a proton-sensitive fluorescence dye, N-allyl-4-(4-methyl-piperazinyl)-1,8-naphthalimide (AMPN), which is bonded covalently to an optical fiber through heat-polymerization. Fluorescence intensity was recorded after the sensor was exposed to different pH buffer solutions or intra-arterial blood in rabbits. Fluorescence intensity with emission peak at 510 nm decreased immediately as the blood pH increased. Linear and reproducible responses were observed when pH ranges from 6.8 to 8.0 with resolution of 0.03 pH units. The correlation coefficients between the pH sensor and the conventional blood gas analyzer was 0.93 in vivo (n=75, p<0.001) with a bias and precision of -0.02}0.08 pH units. The pH sensor was stable during measurement for at least 72h. The pH sensor is not sensitive to fluctuations of various ions concentrations and plasma osmosis at pathophysiological limits, suggesting that it is useful for the continuous measurement of blood pH at various clinical settings. |
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Authors:
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W Jin; L Wu; Y Song; J Jiang; X Zhu; D Yang; C Bai |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-20 |
Journal Detail:
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Title: IEEE transactions on bio-medical engineering Volume: - ISSN: 1558-2531 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0012737 Medline TA: IEEE Trans Biomed Eng Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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