| Continuous insulin infusions in neonates: pharmacologic availability of insulin in intravenous solutions. | |
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MedLine Citation:
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PMID: 8176576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Continuous insulin infusion is sometimes used in very low birth weight infants with glucose intolerance. We studied the availability of insulin to the neonate by means of a laboratory-simulated clinical infusion under both flushed and non-flushed conditions. Although loss of insulin was noted with both solutions (0.5 U/ml), under the nonflushed condition only 55.9% of the prescribed dose for the first 2 hours was delivered before the delivery rate of the flushed system, 71.4%, was approached. These findings have implications for neonatal insulin administration. |
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Authors:
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P S Simeon; M E Geffner; S R Levin; A M Lindsey |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pediatrics Volume: 124 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1994 May |
Date Detail:
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Created Date: 1994-06-03 Completed Date: 1994-06-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 818-20 Citation Subset: AIM; IM |
Affiliation:
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School of Nursing, University of California, Los Angeles. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adsorption Humans Hyperglycemia / drug therapy Infant, Newborn Infusions, Intravenous / instrumentation*, methods Insulin / administration & dosage*, pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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