| Continuous infusion of coagulation factor products. | |
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MedLine Citation:
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PMID: 11978168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To review clinical information related to the use of continuous infusion factor products in patients with hemophilia. Specifically, case reports and open-label trials are summarized involving the use of factor VIII and recombinant factor VIIa for a variety of indications including surgical prophylaxis, acute bleeding, primary prevention, and management of inhibitors. In addition, issues surrounding the use of continuous infusion of factor products such as pharmacokinetic rationale, stability/sterility, and cost are reviewed. DATA SOURCES: Primary and review articles were identified through a MEDLINE search (1990-June 2001) and through secondary sources. STUDY SELECTION AND DATA EXTRACTION: All articles identified from the data sources were evaluated, and all information deemed relevant was included in this review. DATA SYNTHESIS: Data concerning the administration of factor products are primarily detailed in open-label trials and case reports. Comparisons between intermittent bolus injections and continuous infusion of factor products are limited and primarily compare continuous infusion regimens with historical controls. The rationale behind the continuous-infusion approach is linked to the pharmacokinetics of factor products administered via this route. Pharmacokinetic data reveal that, with continuous infusion of factor products, a reduction in clearance and a maintenance of factor serum concentrations are noted. CONCLUSIONS: Administration of factor products (factor VIII and recombinant factor VIIa) via continuous infusion has produced favorable hemostatic effects compared with intermittent bolus injections. The advantages of continuous infusion include maintenance of a constant factor concentration, thereby reducing risk of bleeding from excessively low trough concentrations, and a decrease in factor consumption related to a reduction in factor clearance with constant infusion. Manufacturers recommend using reconstituted factor products either immediately or within 1-3 hours after reconstitution; however, several studies have found the products to be stable and sterile for longer periods. |
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Authors:
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Joan M Stachnik; Michael P Gabay |
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Publication Detail:
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Type: Case Reports; Comparative Study; Journal Article; Review |
Journal Detail:
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Title: The Annals of pharmacotherapy Volume: 36 ISSN: 1060-0280 ISO Abbreviation: Ann Pharmacother Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-04-29 Completed Date: 2002-10-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: United States |
Other Details:
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Languages: eng Pagination: 882-91 Citation Subset: IM |
Affiliation:
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Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street (M/C 886), Rm. 164, Chicago, IL 60612-7230, USA. stachnik@uic.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Coagulation Factors
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administration & dosage,
adverse effects,
therapeutic use* Clinical Trials as Topic Factor VII / administration & dosage, adverse effects, therapeutic use Factor VIII / administration & dosage, adverse effects, therapeutic use Factor VIIa Hemophilia A / drug therapy* Hemorrhage / etiology Humans Infusion Pumps / adverse effects Recombinant Proteins / administration & dosage, adverse effects, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Blood Coagulation Factors; 0/Recombinant Proteins; 0/recombinant FVIIa; 9001-25-6/Factor VII; 9001-27-8/Factor VIII; EC 3.4.21.21/Factor VIIa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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