| Continuous flow left ventricular assist device improves functional capacity and quality of life of advanced heart failure patients. | |
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MedLine Citation:
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PMID: 20413033 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: This study sought to assess the impact of continuous flow left ventricular assist devices (LVADs) on functional capacity and heart failure-related quality of life. BACKGROUND: Newer continuous-flow LVAD are smaller and quieter than pulsatile-flow LVADs. METHODS: Data from advanced heart failure patients enrolled in the HeartMate II LVAD (Thoratec Corporation, Pleasanton, California) bridge to transplantation (BTT) (n = 281) and destination therapy (DT) (n = 374) trials were analyzed. Functional status (New York Heart Association [NYHA] functional class, 6-min walk distance, patient activity scores), and quality of life (Minnesota Living With Heart Failure [MLWHF] and Kansas City Cardiomyopathy Questionnaires [KCCQ]) were collected before and after LVAD implantation. RESULTS: Compared with baseline, LVAD patients demonstrated early and sustained improvements in functional status and quality of life. Most patients had NYHA functional class IV symptoms at baseline. Following implant, 82% (BTT) and 80% (DT) of patients at 6 months and 79% (DT) at 24 months improved to NYHA functional class I or II. Mean 6-min walk distance in DT patients was 204 m in patients able to ambulate at baseline, which improved to 350 and 360 m at 6 and 24 months. There were also significant and sustained improvements from baseline in both BTT and DT patients in median MLWHF scores (by 40 and 42 U in DT patients, or 52% and 55%, at 6 and 24 months, respectively), and KCCQ overall summary scores (by 39 and 41 U, or 170% and 178%). CONCLUSIONS: Use of a continuous flow LVAD in advanced heart failure patients results in clinically relevant improvements in functional capacity and heart failure-related quality of life. |
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Authors:
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Joseph G Rogers; Keith D Aaronson; Andrew J Boyle; Stuart D Russell; Carmelo A Milano; Francis D Pagani; Brooks S Edwards; Soon Park; Ranjit John; John V Conte; David J Farrar; Mark S Slaughter; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 55 ISSN: 1558-3597 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-23 Completed Date: 2010-05-06 Revised Date: 2010-11-12 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1826-34 Citation Subset: AIM; IM |
Copyright Information:
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Copyright (c) 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Duke University Medical Center, Durham, NC 27710, USA. joseph.rogers@duke.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Equipment Design Female Heart Failure / physiopathology, therapy* Heart Ventricles Heart-Assist Devices* Humans Male Middle Aged Quality of Life Questionnaires Walking / physiology |
| Comments/Corrections | |
Comment In:
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J Am Coll Cardiol. 2010 Apr 27;55(17):1835-6
[PMID:
20413034
]
Nat Rev Cardiol. 2010 Jul;7(7):360 [PMID: 20590000 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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