| Continuous flow Overhauser dynamic nuclear polarization of water in the fringe field of a clinical magnetic resonance imaging system for authentic image contrast. | |
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MedLine Citation:
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PMID: 20541445 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe and demonstrate a system to generate hyperpolarized water in the 0.35 T fringe field of a clinical 1.5 T whole-body magnetic resonance imaging (MRI) magnet. Once generated, the hyperpolarized water is quickly and continuously transferred from the 0.35 T fringe to the 1.5 T center field of the same magnet for image acquisition using standard MRI equipment. The hyperpolarization is based on Overhauser dynamic nuclear polarization (DNP), which effectively and quickly transfers the higher spin polarization of free radicals to nuclear spins at ambient temperatures. We visualize the dispersion of hyperpolarized water as it flows through water-saturated systems by utilizing an observed -15-fold DNP signal enhancement with respect to the unenhanced (1)H MRI signal of water at 1.5 T. The experimental DNP apparatus presented here is readily portable and can be brought to and used with any conventional unshielded MRI system. A new method of immobilizing radicals to gel beads via polyelectrolyte linker arms is described, which led to superior flow Overhauser DNP performance compared to previously presented gels. We discuss the general applicability of Overhauser DNP of water and aqueous solutions in the fringe field of commercially available magnets with central fields up to 4.7 T. |
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Authors:
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Mark D Lingwood; Ting Ann Siaw; Napapon Sailasuta; Brian D Ross; Pratip Bhattacharya; Songi Han |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-05-19 |
Journal Detail:
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Title: Journal of magnetic resonance (San Diego, Calif. : 1997) Volume: 205 ISSN: 1096-0856 ISO Abbreviation: J. Magn. Reson. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9707935 Medline TA: J Magn Reson Country: United States |
Other Details:
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Languages: eng Pagination: 247-54 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Chromatography, High Pressure Liquid Electromagnetic Fields Free Radicals Image Processing, Computer-Assisted Magnetic Resonance Imaging / instrumentation, methods* Magnetic Resonance Spectroscopy Microwaves Phantoms, Imaging Water / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
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CA122513/CA/NCI NIH HHS; NS048589/NS/NINDS NIH HHS; R21 CA118509/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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