Document Detail

Continuous extrapleural paravertebral infusion of bupivacaine for post-thoracotomy analgesia in young infants.
MedLine Citation:
PMID:  8679355     Owner:  NLM     Status:  MEDLINE    
We have studied the efficacy of a continuous paravertebral infusion of bupivacaine for the management of post-thoracotomy pain in 20 infants with a median age of 5.3 weeks (range 2 days to 20 weeks). Immediately before chest closure, 0.25% bupivacaine 1.25 mg kg-1 was injected into an extrapleural paravertebral catheter, inserted under direct vision. A continuous infusion of 0.25% bupivacaine 0.5 mg kg-1 h-1 was commenced 1 h later and terminated after 24 h. We found that extrapleural paravertebral catheter placement under direct vision was easy in neonates and infants. The technique provided effective postoperative pain relief in 18 (90%) patients and the failure in two (10%) infants was attributed to catheter block. Mean maximum serum concentrations of bupivacaine after the loading dose and during infusion were 1.03 (SD 0.56) and 2.00 (0.63) microgram ml-1, respectively. There were no major complications relating to the technique and we conclude that extrapleural paravertebral block is a simple and effective method for post-thoracotomy analgesia in young infants.
M K Karmakar; P D Booker; R Franks; M Pozzi
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  76     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-08-21     Completed Date:  1996-08-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  811-5     Citation Subset:  IM    
Royal Liverpool Children's NHS Trust, Liverpool.
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MeSH Terms
Anesthesia, Spinal / methods*
Anesthetics, Local / administration & dosage*
Bupivacaine / administration & dosage*
Infant, Newborn
Pain, Postoperative / prevention & control*
Reg. No./Substance:
0/Anesthetics, Local; 2180-92-9/Bupivacaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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