Document Detail

Continuous exposure of the chick embryo to l-alpha-noracetylmethadol does not alter brain protein or nucleic acid content.
MedLine Citation:
PMID:  6171394     Owner:  NLM     Status:  MEDLINE    
Injection of l-alpha-noracetylmethadol (NLAAM), the active des-methyl metabolite of l-alpha-acetylmethadol, into chicken eggs on the 3rd day of embryonic development produced no deficits in body or brain weight, or brain nucleic acid and protein content in the 20-day check embryo. NLAAM decreased embryo viability in a dose-dependent manner as early as day 4. At this time measureable levels of radiolabeled NLAAM could be detected in the embryo; further sampling of whole embryos or embryo brains demonstrated continual exposure to NLAAM throughout development. The present report describes the utility of an avian model in studying the direct effects of prenatal opiate exposure on development.
M D Kuwahara; S B Sparber
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental pharmacology and therapeutics     Volume:  3     ISSN:  0379-8305     ISO Abbreviation:  Dev Pharmacol Ther     Publication Date:  1981  
Date Detail:
Created Date:  1982-02-12     Completed Date:  1982-02-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8003947     Medline TA:  Dev Pharmacol Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  12-24     Citation Subset:  IM    
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MeSH Terms
Brain / drug effects*,  embryology,  metabolism
Chick Embryo
DNA / metabolism*
Methadone / analogs & derivatives*
Methadyl Acetate / analogs & derivatives*,  pharmacology
Nerve Tissue Proteins / metabolism*
Organ Size
RNA / metabolism*
Grant Support
Reg. No./Substance:
0/Nerve Tissue Proteins; 1477-39-0/paracymethadol; 509-74-0/Methadyl Acetate; 63231-63-0/RNA; 76-99-3/Methadone; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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