| Continuous duodenal infusions of levodopa: plasma concentrations and motor fluctuations in Parkinson's disease. | |
| | |
MedLine Citation:
|
PMID: 3349496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Four parkinsonian patients received continuous duodenal infusions of levodopa (LD) for severe "on-off" phenomena associated with Sinemet (carbidopa/levodopa) therapy. All patients had marked decreases in motor fluctuations on the infusions compared with tablets. Two factors that appear related to this improvement are the ability of duodenal infusions to produce steadier plasma LD concentrations and/or to maintain LD concentrations above a minimum threshold needed to achieve the "on" state. |
| | |
Authors:
|
J I Sage; L Schuh; R E Heikkila; R C Duvoisin |
Related Documents
:
|
16364056 - Effect of itraconazole on the pharmacokinetics of atenolol. 22654846 - Transformation of a microprolactinoma into a mixed growth hormone and prolactin-secreti... 938966 - Radioimmunoassay of antidiuretic hormone during morphine anaesthesia. 1159016 - Determination of nitrazepam in serum by gas-liquid chromatography. application in bioav... 1316586 - Frusemide therapy and intact parathyroid hormone plasma concentrations in chronic renal... 17566776 - Growth hormone action in puberty: effects by gender. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical neuropharmacology Volume: 11 ISSN: 0362-5664 ISO Abbreviation: Clin Neuropharmacol Publication Date: 1988 Feb |
Date Detail:
|
Created Date: 1988-04-25 Completed Date: 1988-04-25 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7607910 Medline TA: Clin Neuropharmacol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 36-44 Citation Subset: IM |
Affiliation:
|
Department of Neurology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick 08903. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Duodenum Humans Intubation, Gastrointestinal Levodopa / administration & dosage*, pharmacokinetics, therapeutic use Male Middle Aged Parkinson Disease / drug therapy*, physiopathology Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Levodopa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Identification of 4-hydroxy-N-desmethyltamoxifen as a metabolite of tamoxifen in human bile.
Next Document: Does anisocoria by clonidine reflect a central sympathetic dysfunction in cluster headache?