| Continuous distal oesophageal acidification decreases postprandial gastric acidity in healthy human subjects. | |
| | |
MedLine Citation:
|
PMID: 19053984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Previously, we hypothesized that exposing the distal oesophagus to acid signals the stomach to decrease gastric acidity. AIM: To test the hypothesis that exposing the distal oesophagus to acid signals the stomach to decrease gastric acidity. METHODS: Twenty-two healthy humans ingested a standard meal containing [(14)C]octanoic acid and [(13)C]glycine over 30 min on 2 separate occasions. Gastric pH was measured for 90 min before and 240 min after the meal. 10 mm HCl was infused continuously at 1 mL/min into either the distal oesophagus or stomach in a 2-way crossover fashion for 60 min before and 240 min after the meal. Gastric emptying of solid and liquid were determined with breath tests. RESULTS: Compared to gastric infusion, oesophageal infusion significantly decreased gastric acidity after the meal, but not before the meal and the magnitude of the decrease varied directly with gastric acidity. Gastric emptying of solid or liquid with oesophageal infusion was not significantly different from that with gastric infusion. CONCLUSIONS: These findings support the hypothesis of the existence of a physiological oesophago-gastric feedback mechanism that might contribute to regulation of postprandial gastric acidity. Oesophageal acidification might decode gastric information and signal the stomach to decrease gastric acidity. Further studies are needed to assess the characteristics of such feedback mechanism in-patients with gastro-oesophageal reflux disease (GERD). |
| | |
Authors:
|
K Blondeau; D Sifrim; J D Gardner |
Related Documents
:
|
6600204 - Bleeding from the bypassed stomach following gastric bypass. 11860414 - Minor effects of helicobacter pylori on gastric secretion and dose of lansoprazole duri... 10677784 - Treatments of peptic ulcer. 17228794 - Inhibitory effects of acidic xylooligosaccharide on stress-induced gastric inflammation... 6271944 - In vitro and in vivo interactions of delta 8-tetra-hydrocannabinol and its metabolites ... 22008254 - Actinoplanes teichomyceticus atcc 31121 as a cell factory for producing teicoplanin. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-28 |
Journal Detail:
|
Title: Alimentary pharmacology & therapeutics Volume: 29 ISSN: 1365-2036 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2009 Mar |
Date Detail:
|
Created Date: 2009-02-03 Completed Date: 2009-07-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: England |
Other Details:
|
Languages: eng Pagination: 561-70 Citation Subset: IM |
Affiliation:
|
Center for Gastroenterological Research, Catholic University of Leuven, Leuven, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Feedback
/
drug effects*,
physiology Gastric Acid / physiology* Gastric Acidity Determination Gastric Emptying / drug effects* Humans Hydrogen-Ion Concentration / drug effects Postprandial Period Stomach / drug effects*, physiology Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Quantitative tests of liver function measure hepatic improvement after sustained virological respons...
Next Document: Systematic review: Helicobacter pylori infection and impaired drug absorption.