| Continuous combination oral contraceptive pills to eliminate withdrawal bleeding: a randomized trial. | |
| | |
MedLine Citation:
|
PMID: 12681866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To compare bleeding profiles of a traditional 28-day oral contraceptive pill cycle with continuous administration. METHODS: After a 28-day run-in cycle, women were randomized to either 28-day cycles (21 active pills and a pill-free week) or continuous use of the same 20 microg ethinyl estradiol/100 microg levonorgestrel formulation for 12 study cycles (336 days). The number of bleeding and spotting days were measured by daily diary. A subset underwent cycle 1 (n = 16), and nine (n = 14) pelvic ultrasound and endometrial histology sampling. Blood pressure, weight, hemoglobin, and adverse events were measured at revisit. The sample size with 80% power to detect a 67% reduction in bleeding days required 27 subjects in each arm. RESULTS: Of the 79 subjects randomized, 28 (70%) of the 28-day cycle and 32 (82%) of the continuous-use subjects completed the entire study (P =.6). With continuous use, 49%, 68%, and 88% of women reported no bleeding during cycles 2, 6, and 12, respectively. Amenorrhea or infrequent bleeding was present in 68% of continuous users during cycles 1-3 and increased to 88% during cycles 10-12. Spotting during cycle days 1-21 increased initially with continuous use but reduced over time, and by 9 months was less than the spotting reported by cyclic users. Adverse events, blood pressure, weight, and hemoglobin findings were similar between groups. CONCLUSION: Extension of the 28-day oral contraceptive cycle to continuous use with a low-estrogen dose combination oral birth control pill resulted in significantly fewer bleeding days. |
| | |
Authors:
|
Leslie Miller; James P Hughes |
Related Documents
:
|
760766 - The effect of danazol on menorrhagia, coagulation mechanisms, haematological indices an... 9848316 - Randomized clinical trial of two laparoscopic treatments of endometriomas: cystectomy v... 20844886 - Electrocoagulation versus suture after laparoscopic stripping of ovarian endometriomas ... 15172086 - Prolonged use of gonadotropin-releasing hormone agonist and tibolone as add-back therap... 14750756 - Nonpenetrating deep sclerectomy with the use of adjunctive mitomycin c. 19089776 - Use of diazepam for hyperemesis gravidarum. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Obstetrics and gynecology Volume: 101 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2003 Apr |
Date Detail:
|
Created Date: 2003-04-08 Completed Date: 2003-04-24 Revised Date: 2009-10-26 |
Medline Journal Info:
|
Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
|
Languages: eng Pagination: 653-61 Citation Subset: AIM; IM |
Affiliation:
|
Departments of Obstetrics & Gynecology, University of Washington, Seattle, Washington, USA. lmiller@u.washington.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Contraceptives, Oral, Combined / administration & dosage* Drug Administration Schedule Endometrium / pathology, ultrasonography Ethinyl Estradiol / administration & dosage* Female Humans Levonorgestrel / administration & dosage* Menstrual Cycle / drug effects* Treatment Outcome Uterine Hemorrhage / prevention & control* |
| Chemical | |
Reg. No./Substance:
|
0/Contraceptives, Oral, Combined; 57-63-6/Ethinyl Estradiol; 797-63-7/Levonorgestrel |
| Comments/Corrections | |
Comment In:
|
J Fam Pract. 2003 Aug;52(8):601-2
[PMID:
12899813
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Condyloma in pregnancy is strongly predictive of juvenile-onset recurrent respiratory papillomatosis...
Next Document: Effect of genital prolapse on assessment of bladder neck mobility by the Q-tip test.