| Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. | |
| | |
MedLine Citation:
|
PMID: 21113154 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The liver and exocrine pancreas share a common structure, with functioning units (hepatic plates and pancreatic acini) connected to the ductal tree. Here we show that Sox9 is expressed throughout the biliary and pancreatic ductal epithelia, which are connected to the intestinal stem-cell zone. Cre-based lineage tracing showed that adult intestinal cells, hepatocytes and pancreatic acinar cells are supplied physiologically from Sox9-expressing progenitors. Combination of lineage analysis and hepatic injury experiments showed involvement of Sox9-positive precursors in liver regeneration. Embryonic pancreatic Sox9-expressing cells differentiate into all types of mature cells, but their capacity for endocrine differentiation diminishes shortly after birth, when endocrine cells detach from the epithelial lining of the ducts and form the islets of Langerhans. We observed a developmental switch in the hepatic progenitor cell type from Sox9-negative to Sox9-positive progenitors as the biliary tree develops. These results suggest interdependence between the structure and homeostasis of endodermal organs, with Sox9 expression being linked to progenitor status. |
| | |
Authors:
|
Kenichiro Furuyama; Yoshiya Kawaguchi; Haruhiko Akiyama; Masashi Horiguchi; Sota Kodama; Takeshi Kuhara; Shinichi Hosokawa; Ashraf Elbahrawy; Tsunemitsu Soeda; Masayuki Koizumi; Toshihiko Masui; Michiya Kawaguchi; Kyoichi Takaori; Ryuichiro Doi; Eiichiro Nishi; Ryosuke Kakinoki; Jian Min Deng; Richard R Behringer; Takashi Nakamura; Shinji Uemoto |
Related Documents
:
|
20369944 - The role of time delays, slow processes, and chaos in modulating the cell-cycle clock. 3982504 - Levels of c-myc oncogene mrna are invariant throughout the cell cycle. 9410874 - Deregulated expression of the ranbp1 gene alters cell cycle progression in murine fibro... 20462454 - Expression of human eukaryotic initiation factor 3f oscillates with cell cycle in a549 ... 16450174 - Ultrastructure of cell contacts of fetal and adult leydig cells in the rat: a systemati... 9710604 - Induction of differentiation in normal human keratinocytes by adenovirus-mediated intro... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-11-28 |
Journal Detail:
|
Title: Nature genetics Volume: 43 ISSN: 1546-1718 ISO Abbreviation: Nat. Genet. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-10 Completed Date: 2011-02-22 Revised Date: 2011-05-20 |
Medline Journal Info:
|
Nlm Unique ID: 9216904 Medline TA: Nat Genet Country: United States |
Other Details:
|
Languages: eng Pagination: 34-41 Citation Subset: IM |
Affiliation:
|
Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Differentiation Epithelial Cells / cytology, metabolism Intestines / cytology, metabolism* Liver / cytology, metabolism* Mice Mice, Knockout Pancreas / cytology, metabolism* SOX9 Transcription Factor / genetics, metabolism* Stem Cells / cytology, metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/SOX9 Transcription Factor; 0/Sox9 protein, mouse |
| Comments/Corrections | |
Comment In:
|
Nat Genet. 2011 Jan;43(1):9-10
[PMID:
21217637
]
Hepatology. 2011 Apr;53(4):1393-6 [PMID: 21480343 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Common variants in DGKK are strongly associated with risk of hypospadias.
Next Document: T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract.