| Continuous arterial spin labeling perfusion magnetic resonance imaging findings in postpartum vasculopathy. | |
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MedLine Citation:
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PMID: 11677889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Postpartum vasculopathy (PPV) is a rare heterogeneous nonatherosclerotic vasculopathy that occurs in the puerperium. It occurs spontaneously but may be triggered by vasoconstrictor substances. The angiographic findings vary and include narrowing of the intracranial arteries and vasospasm. The angiographic findings and the occurrence of ischemic infarcts suggest that cerebral blood flow (CBF) is impaired in PPV. The purpose of this study is to determine CBF in patients with PPV. The authors conducted a case study of 3 patients with clinical and laboratory criteria for PPV examined during a 2-year period. Clinical examination, computed tomography imaging, structural magnetic resonance imaging (MRI), cerebral angiography, and continuous arterial spin labeling perfusion (CASL-PI) MRI were performed in all patients. Mean global CBF was determined, and perfusion maps were visually inspected. The CBF values and perfusion maps were correlated with the clinical symptoms and the neuroimaging findings. Three women were studied (22, 34, and 36 years old). The median time of presentation was 4 days postpartum. One presented with intracranial hemorrhage and diffuse arterial narrowing, the other 2 with stroke-like lesions, encephalopathy, and segmental narrowing mainly in the posterior circulation. CASL-PI was performed within 1 week of symptom onset in all 3 patients. Global mean CBF values were 51.8, 39.3, and 41.8 cc/100 g/min. Although global CBF was mildly diminished, it was above ischemic levels. Visual inspection of the CASL-PI perfusion maps did not reveal areas of focal hypoperfusion or hyperperfusion. In this series of patients with PPV, CBF was close to normal. Although angiography often reveals diffuse arterial narrowing, the CBF values encountered in this study do not support a state of generalized or focal oligoemia. Vasomotor tone may change intermittently in patients with PPV. |
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Authors:
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J A Chalela; S E Kasner; M McGarvey; D C Alsop; J A Detre |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: 11 ISSN: 1051-2284 ISO Abbreviation: J Neuroimaging Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-25 Completed Date: 2001-12-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: United States |
Other Details:
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Languages: eng Pagination: 444-6 Citation Subset: IM |
Affiliation:
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Department of Neurology, Hospital of the University of Pennsylvania, USA. chalelaj@ninds.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cerebral Angiography Cerebrovascular Circulation Cerebrovascular Disorders / diagnosis* Diagnosis, Differential Female Humans Magnetic Resonance Imaging / methods* Postpartum Period Spin Labels |
| Chemical | |
Reg. No./Substance:
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0/Spin Labels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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