Document Detail

Continuous adaptation of the dialysis prescription maintains adequate Kprt/V in CAPD patients.
MedLine Citation:
PMID:  11007374     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To analyze the effect of individual adaptation of the dialysis prescription in continuous ambulatory peritoneal dialysis (CAPD), as compensation for the decline of residual renal function (RRF), on peritoneal (Kpt/V) and total (Kprt/V) urea clearance as well as on peritoneal (Kpcr) and total weekly creatinine clearances (CCr). DESIGN: Retrospective analysis of a 2-year period. PATIENTS: We analyzed 18 patients [15 male, 3 female; mean age 58.2 (24 - 80) years]. MAIN OUTCOME MEASURES: Correlations between increased dialysis prescription and Kpt/V, Kprt/V, and Kpcr. Kprt/V and CCr measurements were based on a 24-hour dialysate and urine collection. Measurements were performed over a time period of 3 to 6 months. RESULTS: The results show a linear correlation between Kpt/V and Kpcr and the prescribed volume by kilogram body weight. Kprt/V was increased slightly by increasing the dialysis prescription. Dialysate-to-plasma (D/P) ratios of urea and creatinine remained unchanged. The mean prescribed dialysate volume increased from 7.4+/-1.1 L to 10.6+/-2.5 L. Mean Kprt/V could be maintained on a stable level for a 36-month period. CONCLUSION: By adapting the dialysis prescription on an individual basis to the continuous decline of RRF, and taking the patient's body weight into account in the prescription decision, the increases in Kpt/V offset the decline in RRF. We recommend early individualization of prescription for patients on CAPD.
H Andersson; M Buxbaum; F T Meisl
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  20     ISSN:  0896-8608     ISO Abbreviation:  Perit Dial Int     Publication Date:    2000 Jul-Aug
Date Detail:
Created Date:  2001-01-03     Completed Date:  2001-03-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  423-8     Citation Subset:  IM    
Department of Nephrology and Dialysis, Wilhelminenspital, Vienna, Austria.
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MeSH Terms
Aged, 80 and over
Middle Aged
Peritoneal Dialysis, Continuous Ambulatory*
Peritoneum / metabolism*
Retrospective Studies
Urea / metabolism*
Reg. No./Substance:
Comment On:
Perit Dial Int. 2000 Jul-Aug;20(4):418-22   [PMID:  11007373 ]
Comment In:
Perit Dial Int. 2000 Jul-Aug;20(4):386-9   [PMID:  11007368 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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