| Continuous adaptation of the dialysis prescription maintains adequate Kprt/V in CAPD patients. | |
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MedLine Citation:
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PMID: 11007374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To analyze the effect of individual adaptation of the dialysis prescription in continuous ambulatory peritoneal dialysis (CAPD), as compensation for the decline of residual renal function (RRF), on peritoneal (Kpt/V) and total (Kprt/V) urea clearance as well as on peritoneal (Kpcr) and total weekly creatinine clearances (CCr). DESIGN: Retrospective analysis of a 2-year period. PATIENTS: We analyzed 18 patients [15 male, 3 female; mean age 58.2 (24 - 80) years]. MAIN OUTCOME MEASURES: Correlations between increased dialysis prescription and Kpt/V, Kprt/V, and Kpcr. Kprt/V and CCr measurements were based on a 24-hour dialysate and urine collection. Measurements were performed over a time period of 3 to 6 months. RESULTS: The results show a linear correlation between Kpt/V and Kpcr and the prescribed volume by kilogram body weight. Kprt/V was increased slightly by increasing the dialysis prescription. Dialysate-to-plasma (D/P) ratios of urea and creatinine remained unchanged. The mean prescribed dialysate volume increased from 7.4+/-1.1 L to 10.6+/-2.5 L. Mean Kprt/V could be maintained on a stable level for a 36-month period. CONCLUSION: By adapting the dialysis prescription on an individual basis to the continuous decline of RRF, and taking the patient's body weight into account in the prescription decision, the increases in Kpt/V offset the decline in RRF. We recommend early individualization of prescription for patients on CAPD. |
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Authors:
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H Andersson; M Buxbaum; F T Meisl |
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Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis Volume: 20 ISSN: 0896-8608 ISO Abbreviation: Perit Dial Int Publication Date: 2000 Jul-Aug |
Date Detail:
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Created Date: 2001-01-03 Completed Date: 2001-03-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8904033 Medline TA: Perit Dial Int Country: CANADA |
Other Details:
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Languages: eng Pagination: 423-8 Citation Subset: IM |
Affiliation:
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Department of Nephrology and Dialysis, Wilhelminenspital, Vienna, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Female Humans Male Middle Aged Peritoneal Dialysis, Continuous Ambulatory* Peritoneum / metabolism* Retrospective Studies Urea / metabolism* |
| Chemical | |
Reg. No./Substance:
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57-13-6/Urea |
| Comments/Corrections | |
Comment On:
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Perit Dial Int. 2000 Jul-Aug;20(4):418-22
[PMID:
11007373
]
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Comment In:
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Perit Dial Int. 2000 Jul-Aug;20(4):386-9
[PMID:
11007368
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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