Document Detail

Continuous venovenous hemofiltration rapidly lowers toxic metabolites in a patient with MSUD and imminent cerebral herniation.
MedLine Citation:
PMID:  20309789     Owner:  NLM     Status:  MEDLINE    
Maple syrup urine disease (MSUD) is an inborn error of amino acid metabolism. During catabolic stress encephalopathy and brain swelling that can culminate in brain herniation may occur. Beyond the neonatal period, these metabolic decompensations normally can be treated with a conservative dietary emergency regimen. Nevertheless in exceptionally severe cases also older patients may require extracorporeal interventions. We present the case of a 12-year-old patient with cerebral edema and imminent cerebral herniation. Continuous venovenous hemofiltration (CVVH) caused a prompt decrease of the toxic metabolite levels as well as an improvement of the patient's condition.
E Thimm; B Hadzik; T Höhn
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-03-22
Journal Detail:
Title:  Klinische Pädiatrie     Volume:  222     ISSN:  1439-3824     ISO Abbreviation:  Klin Padiatr     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-28     Completed Date:  2010-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326144     Medline TA:  Klin Padiatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  264-5     Citation Subset:  IM    
Copyright Information:
(c) Georg Thieme Verlag KG Stuttgart-New York.
Department of General Paediatrics, University Children's Hospital Düsseldorf, Moorenstrasse 5, Düsseldorf, Germany.
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MeSH Terms
Amino Acids, Branched-Chain / blood*
Brain Edema / radiography,  therapy*
Encephalocele / prevention & control*,  radiography
Leucine / blood
Maple Syrup Urine Disease / radiography,  therapy*
Tomography, X-Ray Computed
Reg. No./Substance:
0/Amino Acids, Branched-Chain; 61-90-5/Leucine

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