| Continuous Parenteral and Enteral Nutrition Induces Metabolic Dysfunction in Neonatal Pigs. | |
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MedLine Citation:
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PMID: 22549765 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: We previously showed that parenteral nutrition (PN) compared with formula feeding results in hepatic insulin resistance and steatosis in neonatal pigs. The current aim was to test whether the route of feeding (intravenous [IV] vs enteral) rather than other feeding modalities (diet, pattern) had contributed to the outcome. METHODS: Neonatal pigs were fed enterally or parenterally for 14 days with 1 of 4 feeding modalities as follows: (1) enteral polymeric formula intermittently (FORM), (2) enteral elemental diet (ED) intermittently (IEN), (3) enteral ED continuously (CEN), and (4) parenteral ED continuously (PN). Subgroups of pigs underwent IV glucose tolerance tests (IVGTT) and hyperinsulinemic-euglycemic clamps (CLAMP). Following CLAMP, pigs were euthanized and tissues collected for further analysis. RESULTS: Insulin secretion during IVGTT was significantly higher and glucose infusion rates during CLAMP were lower in CEN and PN than in FORM and IEN. Endogenous glucose production rate was suppressed to zero in all groups during CLAMP. In the fed state, plasma glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide (GLP)-1, and GLP-2 were different between feeding modalities. Insulin receptor phosphorylation in liver and muscle was decreased in IEN, CEN, and PN compared with FORM. Liver weight was highest in PN. Steatosis and myeloperoxidase (MPO) activity tended to be highest in PN and CEN. Enterally fed groups had higher plasma GLP-2 and jejunum weight compared with PN. CONCLUSIONS: PN and enteral nutrition (EN) when given continuously as an elemental diet reduces insulin sensitivity and the secretion of key gut incretins. The intermittent vs continuous pattern of EN produced the optimal effect on metabolic function. |
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Authors:
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Barbara Stoll; Patrycja Jolanta Puiman; Liwei Cui; Xiaoyan Chang; Nancy Marie Benight; Caroline Bauchart-Thevret; Bolette Hartmann; Jens Juul Holst; Douglas Guy Burrin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-1 |
Journal Detail:
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Title: JPEN. Journal of parenteral and enteral nutrition Volume: - ISSN: 0148-6071 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804134 Medline TA: JPEN J Parenter Enteral Nutr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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USDA/ARS Children's Nutrition Research Center, Houston, Texas. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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