| Continuous Glucose Monitoring in Gastroparesis. | |
| | |
MedLine Citation:
|
PMID: 21735078 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Delayed gastric emptying can alter glucose levels in diabetic patients; hyperglycemia can delay gastric emptying. Continuous glucose monitoring (CGM) may be useful to assess the relationship between gastric emptying and blood glucose levels. AIMS: The aims of this study were to compare the postprandial blood glucose profile of patients with type 2 diabetes mellitus (T2DM) with and without gastroparesis, normal subjects, and patients with idiopathic gastroparesis (IG), and also to determine the effect of different meal compositions on glucose regulation in T2DM and normals. METHODS: Seven patients with IG, seven T2DM with gastroparesis, ten non-gastroparetic T2DM, and ten normal subjects underwent CGM during a low fat (Eggbeaters) meal. Glucose profiles were also studied in T2DM and normal subjects after high fat, high fiber, spicy, and Ensure liquid nutrient meals. RESULTS: After the Eggbeaters meal, the glucose profile of IGs and normals were similar. Diabetic patients with gastroparesis had similar peak postprandial blood glucose to nongastroparetic diabetics (231 ± 26 vs. 232 ± 18 mg/dl), but had a higher postprandial blood glucose at the end of the 4 h study (187 ± 26 mg/dl vs. 97 ± 10; P = 0.01). In contrast to normals, non-gastroparetic diabetics had higher mean postprandial blood sugar after the Eggbeaters meal (173 ± 5 mg/dl) compared to high fat (157 ± 3; P = 0.002), spicy (133 ± 2; P < 0.001) and Ensure meals (152 ± 1; P < 0.001). CONCLUSIONS: Blood glucose monitoring provides insight to the presence of gastroparesis in diabetic patients: diabetic gastroparetics had prolonged postprandial hyperglycemic profile as compared to non-gastroparetic diabetics. Of the meals tested, the low fat (Eggbeaters) meal was associated with the highest mean postprandial glucose in diabetics. |
| | |
Authors:
|
Zeeshan Ramzan; Frank Duffy; Javier Gomez; Robert S Fisher; Henry P Parkman |
Related Documents
:
|
19648768 - An unusual case of extensive xanthogranulomatous orchitis in a diabetic patient. 10876988 - Suicide of a diabetic by inducing hyperglycemic coma. 11596158 - Presence of cystic fibrosis-related diabetes mellitus is tightly linked to poor lung fu... 15531988 - Moving from undiagnosed to diagnosed diabetes: the patient's perspective. 7621618 - A comparison of the metabolic profiles of fetal and maternal plasma and placenta in nor... 2666268 - Managing diabetes-related infections in the elderly. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-7 |
Journal Detail:
|
Title: Digestive diseases and sciences Volume: - ISSN: 1573-2568 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Gastrointestinal Section, Department of Medicine, Temple University School of Medicine, Parkinson Pavilion, 8th Floor, 3401 North Broad Street, Philadelphia, PA, 19140, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anxiety disorders in children and adolescents with autistic spectrum disorders: a meta-analysis.
Next Document: Severe Acute Pancreatitis During Pregnancy: Eleven Years Experience from a Surgical Intensive Care U...