| Continuous glucose monitoring for evaluation of glycemic excursions after gastric bypass. | |
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MedLine Citation:
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PMID: 21331295 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Background. Hyperinsulinemic hypoglycemia with neuroglycopenia is a rare complication of Roux-en-Y gastric bypass (RYGB). We hypothesized that continuous glucose monitoring (CGM) would be useful to characterize glycemic variability after RYGB. Methods. CGM and mixed meal tolerance testing (MMTT) were performed on sixteen post-RYGB subjects, ten with a history of neuroglycopenia on medical treatment and six asymptomatic controls. Results. 9 of 10 subjects with neuroglycopenia developed hypoglycemia defined by glucose <70 mg/dL on CGM, and 3 of 9 on MMTT. In asymptomatic subjects, 3 of 6 had asymptomatic hypoglycemia during CGM, and 3 of 5 on MMTT. Therefore, the sensitivity and specificity to detect clinically significant hypoglycemia was 90% and 50% for CGM and 33% and 40% for MMTT. Conclusions. Asymptomatic hypoglycemia after RYGB is more frequent than commonly recognized. For clinicians evaluating patients for postbypass neuroglycopenia, CGM may be a valuable diagnostic tool. |
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Authors:
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Florencia Halperin; Mary Elizabeth Patti; Megan Skow; Muhammad Bajwa; Allison B Goldfine |
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Publication Detail:
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Type: Journal Article Date: 2011-02-07 |
Journal Detail:
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Title: Journal of obesity Volume: 2011 ISSN: 2090-0716 ISO Abbreviation: J Obes Publication Date: 2011 |
Date Detail:
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Created Date: 2011-02-18 Completed Date: 2011-07-14 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 101526295 Medline TA: J Obes Country: United States |
Other Details:
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Languages: eng Pagination: 869536 Citation Subset: - |
Affiliation:
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Brigham and Women's Hospital, Boston 02115, MA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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