| Continuous EEG-fMRI in patients with partial epilepsy and focal interictal slow-wave discharges on EEG. | |
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MedLine Citation:
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PMID: 18547769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To verify whether in patients with partial epilepsy and routine electroenecephalogram (EEG) showing focal interictal slow-wave discharges without spikes combined EEG-functional magnetic resonance imaging (fMRI) would localize the corresponding epileptogenic focus, thus providing reliable information on the epileptic source. METHODS: Eight patients with partial epileptic seizures whose routine scalp EEG recordings on presentation showed focal interictal slow-wave activity underwent EEG-fMRI. EEG data were continuously recorded for 24 min (four concatenated sessions) from 18 scalp electrodes, while fMRI scans were simultaneously acquired with a 1.5-Tesla magnetic resonance imaging (MRI) scanner. After recording sessions and MRI artefact removal, EEG data were analyzed offline. We compared blood oxygen level-dependent (BOLD) signal changes on fMRI with EEG recordings obtained at rest and during activation (with and without focal interictal slow-wave discharges). RESULTS: In all patients, when the EEG tracing showed the onset of focal slow-wave discharges on a few lateralized electrodes, BOLD-fMRI activation in the corresponding brain area significantly increased. We detected significant concordance between focal EEG interictal slow-wave discharges and focal BOLD activation on fMRI. In patients with lesional epilepsy, the epileptogenic area corresponded to the sites of increased focal BOLD signal. CONCLUSIONS: Even in patients with partial epilepsy whose standard EEGs show focal interictal slow-wave discharges without spikes, EEG-fMRI can visualize related focal BOLD activation thus providing useful information for pre-surgical planning. |
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Authors:
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Paolo Manganotti; Emanuela Formaggio; Anna Gasparini; Roberto Cerini; Luigi Giuseppe Bongiovanni; Silvia Francesca Storti; Roberto Pozzi Mucelli; Antonio Fiaschi; Mirko Avesani |
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Publication Detail:
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Type: Journal Article Date: 2008-06-10 |
Journal Detail:
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Title: Magnetic resonance imaging Volume: 26 ISSN: 0730-725X ISO Abbreviation: Magn Reson Imaging Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-22 Completed Date: 2009-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8214883 Medline TA: Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 1089-100 Citation Subset: IM |
Affiliation:
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Dipartimento di Scienze Neurologiche e della Visione-Sezione di Neurologia Riabilitativa, University of Verona, 37134 Verona, Italy. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain Mapping
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methods* Diagnosis, Computer-Assisted / methods* Electroencephalography / methods* Epilepsies, Partial / diagnosis* Humans Magnetic Resonance Imaging / methods* Reproducibility of Results Sensitivity and Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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