| Continuity and cascade in offspring of bipolar parents: a longitudinal study of externalizing, internalizing, and thought problems. | |
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MedLine Citation:
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PMID: 20883586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is growing evidence that many offspring of bipolar parents will develop moderate to severe forms of psychopathology during childhood and adolescence. The purpose of this study was to apply growth curve models to evaluate developmental progression with regard to continuity and cascades representative within the context of a family risk study of bipolar disorder (BD). Repeated assessments of externalizing, internalizing, and thought problems, spanning more than a decade, were examined in a total of 94 offspring of parents with BD (O-BD), major depressive disorder (O-UNI), or no significant psychiatric or medical problems (O-WELL). Continuity was defined by the growth curve of the O-WELL group who exhibited low levels of problems from early childhood through late adolescence. Discontinuity, as evidenced by greater complexity of growth curves relative to the O-WELL group, was exhibited in the at- risk offspring groups for internalizing problems. Different patterns of developmental cascades were supported for the at-risk group with O-UNI showing a robust cascade from self-regulatory deficits (externalizing problems) to internalizing problems. There was also support for a cascade from self-regulatory deficits to thought problems across the entire group (with some support that this pattern was accounted for primarily by O-BD). This study not only serves to advance our understanding of the risks associated with a family history of BD, but also provides a novel approach to examining developmental cascades. |
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Authors:
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Bonnie Klimes-Dougan; Jeffrey D Long; Chih-Yuan Steven Lee; Donna S Ronsaville; Philip W Gold; Pedro E Martinez |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Development and psychopathology Volume: 22 ISSN: 1469-2198 ISO Abbreviation: Dev. Psychopathol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2011-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8910645 Medline TA: Dev Psychopathol Country: United States |
Other Details:
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Languages: eng Pagination: 849-66 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of Minnesota, 75 West River Road, Minneapolis, MN 55455, USA. klimes@umn.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00001170 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adolescent Development Bipolar Disorder / etiology, psychology* Case-Control Studies Child Child Development* Child of Impaired Parents / psychology* Cognition Disorders / etiology, psychology Depressive Disorder, Major / etiology, psychology Female Humans Longitudinal Studies Male Models, Psychological Parents / psychology Psychiatric Status Rating Scales Psychological Tests |
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