| Contingent triple-screening for Down syndrome in the second trimester: a feasibility study in Mainland Chinese population. | |
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MedLine Citation:
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PMID: 19967750 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To explore the efficacy of contingent triple-screening for Down syndrome (DS), that is, performing triple-screening in pregnant women with DS risks between 1/270 and 1/1000 at routine double-screening, in a Mainland Chinese population. METHODS: Maternal serum concentrations of alpha fetoprotein (AFP), free-beta human chorionic gonadotropin (free beta-hCG), and unconjugated estriol (uE3) were measured by time-resolved fluoroimmunoassay in 24 double-screening false-negative (DSFN) and 322 double-screening true-negative (DSTN) pregnancies with DS risks between 1/270 and 1/1000 at routine double-screening performed at 15-20 weeks' gestation. DS risk of each pregnancy was calculated by computer software. The detection rate (DR), false-positive rate (FPR), and costs of contingent triple-screening were calculated and compared with routine double-screening methods. RESULTS: Six of 24 DSFN and 3 of 322 DSTN were contingent triple-screening positive. Compared with routine double-screening, DR of contingent triple-screening increased by 10% (from 50% to 60%) without a significant increase of FPR (p > 0.05). When compared with routine triple-screening, uE3 costs in contingent triple-screening were reduced by more than 84.3%. CONCLUSIONS: Second-trimester maternal serum contingent triple-screening could be effective and suitable for prenatal care in Mainland China. Governments and Health Agencies of other developing countries may also find this strategy cost-effective. |
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Authors:
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Zhenwei Xie; Shiming Lu; Hui Li |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 30 ISSN: 1097-0223 ISO Abbreviation: Prenat. Diagn. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-28 Completed Date: 2010-03-09 Revised Date: 2010-05-04 |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 74-6 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 John Wiley & Sons, Ltd. |
Affiliation:
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Women's Hospital, School of Medicine, Zhejiang University, No. 2 Xueshi Road, Hangzhou, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood China / epidemiology Chorionic Gonadotropin, beta Subunit, Human / blood Down Syndrome / blood, diagnosis*, epidemiology Estriol / blood Female Genetic Testing* Gestational Age Humans Mass Screening / economics, methods* Pregnancy Pregnancy Trimester, Second* Prenatal Diagnosis / methods* Retrospective Studies alpha-Fetoproteins / analysis |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/alpha-Fetoproteins; 50-27-1/Estriol |
| Comments/Corrections | |
Comment In:
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Prenat Diagn. 2010 May;30(5):493
[PMID:
20440741
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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