| Context-specific saccadic adaptation in monkeys. | |
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MedLine Citation:
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PMID: 20854833 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When environmental or sensory conditions change suddenly, the brain must be capable of learning different behavioral modes to produce accurate movements under multiple circumstances. A form of this dual-state adaptation known as "context-specific adaptation" has been widely investigated using the saccade gain adaptation paradigm in humans. In this study, we asked whether or not context-specific adaptation of saccade gain exists in monkeys and if so to explore its properties. Here, vertical eye position was used as a context cue for adaptation of horizontal saccade gain. We asked for a gain-increase in one context and gain-decrease in another context, and then determined if a change in the context would invoke switching between the adapted states. After training, our monkeys developed context-specific adaptation: in most cases gain-decrease adaptation could be induced, but there was little or no gain-increase adaptation. This context-specific adaptation developed gradually and switching of gains was evident on the first saccades with each change in context. Along with these results, the retention of an adaptation aftereffect overnight indicates that contextual-specific adaptation in monkeys is not a strategy, but involves a true adaptive process of reorganization in the brain. We suggest that context-specific adaptation in monkeys could be an important tool to provide insights into the mechanisms of saccade adaptation that occurs during the more natural circumstances of daily life. |
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Authors:
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Jing Tian; David S Zee |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-09-18 |
Journal Detail:
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Title: Vision research Volume: 50 ISSN: 1878-5646 ISO Abbreviation: Vision Res. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-08 Completed Date: 2011-05-06 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 0417402 Medline TA: Vision Res Country: England |
Other Details:
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Languages: eng Pagination: 2403-10 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. jtian@jhmi.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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physiology* Animals Cues Eye Movements / physiology Macaca mulatta / physiology* Male Models, Biological Saccades / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 EY001849-36/EY/NEI NIH HHS; R01-EY01849/EY/NEI NIH HHS |
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