| Content and traffic of taurine in hippocampal reactive astrocytes. | |
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MedLine Citation:
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PMID: 20082296 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Taurine is one of the most abundant free amino acids in the mammalian central nervous system, where it is crucial to proper development. Moreover, taurine acts as a neuroprotectant in various diseases; in epilepsy, for example, it has the capacity to reduce or abolish seizures. In the present study, taurine levels has been determine in mice treated with Kainic Acid (KA) and results showed an increase of this amino acid in hippocampus but not in whole brain after 3 and 7 days of KA treatment. This increase occurs when gliosis was observed. Moreover, taurine transporter (TAUT) was found in astrocytes 3 and 7 days after KA treatment, together with an increase in cysteine sulfinic acid decarboxylase (csd) mRNA, that codifies for the rate-limiting enzyme of taurine synthesis, in the hippocampus at the same times after KA treatment. Glial cultures enriched in astrocytes were developed to demonstrate that these cells are responsible for changes in taurine levels after an injury to the brain. The cultures were treated with proinflammatory cytokines to reproduce gliosis. In this experimental model, an increase in the immunoreactivity of GFAP was observed, together with an increase in CSD and taurine levels. Moreover, an alteration in the taurine uptake-release kinetics was detected in glial cells treated with cytokine. All data obtained indicate that astrocytes could play a key role in taurine level changes induced by neuronal damage. More studies are, therefore, needed to clarify the role taurine has in relation to neuronal death and repair. © 2010 Wiley-Liss, Inc. |
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Authors:
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Fèlix Junyent; Luisa De Lemos; Juana Utrera; Sonia Paco; Fernando Aguado; Antoni Camins; Mercè Pallàs; Rafael Romero; Carme Auladell |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hippocampus Volume: 21 ISSN: 1098-1063 ISO Abbreviation: Hippocampus Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9108167 Medline TA: Hippocampus Country: United States |
Other Details:
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Languages: eng Pagination: 185-97 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 Wiley-Liss, Inc. |
Affiliation:
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Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina (IBUB), Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat de Barcelona, Spain. felixjunyent@ub.edu or cauladell@ub.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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