Document Detail

Contemporary outcomes for carotid endarterectomy at a large community-based academic health center.
MedLine Citation:
PMID:  17368835     Owner:  NLM     Status:  MEDLINE    
The North American Symptomatic Carotid Endarterectomy Trial (NASCET) and Asymptomatic Carotid Atherosclerosis Study (ACAS) demonstrated the efficacy of carotid endarterectomy (CEA), but these studies were published 15 and 11 years ago, respectively. We hypothesized that present clinical results of CEA have improved compared with those reported by NASCET/ACAS. Every patient having CEA from January 1999 through December 2003 was reviewed as part of a continuous quality-assurance program. Patient demographics and risk factors were recorded; high-risk patients were identified using inclusion criteria for high-risk carotid stent trials. Primary end points recorded were all neurologic events, deaths, and myocardial infarctions (MIs). Outcomes were reported individually or as combined neurologic events and deaths (traditional NASCET/ACAS methodology) and, similar to recent carotid stent trials, individually, combined, and as a composite that included MI. A total of 1,927 CEAs were performed, 1,140 in men (59%) and 787 in women (41%). The average age was 72 +/- 9 years; 21% of patients were age 80 or older. Symptomatic patients accounted for 717 procedures (37%). Perioperative neurologic event, death, and MI occurred in 1.0%, 0.5%, and 1.3% of patients, respectively. The combined neurologic event and death rate was 1.3% (symptomatic = 1.8%, asymptomatic = 1.1%). High-risk patients comprised 54% of the cohort; the neurologic event and death rate for this group was 1.6%. The composite end point including MI was 3.4%. Severe coronary artery disease and prior ipsilateral CEA significantly correlated with a higher incidence of primary end point complications. In contemporary practice, the perioperative neurologic event rate is significantly less than reported in NASCET/ACAS. Perioperative death and MI rates were similar to those seen in NASCET/ACAS. Neurologic events and death rates were not different between high- and low-risk groups. These data may serve as a guide for the modern vascular specialist weighing open and endovascular options for treatment of carotid artery occlusive disease in both high- and low-risk patients.
Graham W Long; Vijay Nuthakki; Paul G Bove; O William Brown; Charles J Shanley; Phillip J Bendick; Steven Rimar; John Kitzmiller; Gerald B Zelenock
Related Documents :
23016715 - Insight to the pathophysiology of stable angina pectoris.
17880325 - Timing of death and myocardial infarction in patients with non-st elevation acute coron...
8772755 - Early development of accelerated graft coronary artery disease: risk factors and course.
24286975 - A look at the upper heart chamber: the left atrium in chronic kidney disease.
3394185 - Bladder infarct.
1279295 - Dose-response curve of angiographically smooth human epicardial vessel segments to intr...
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-03-26
Journal Detail:
Title:  Annals of vascular surgery     Volume:  21     ISSN:  0890-5096     ISO Abbreviation:  Ann Vasc Surg     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-08     Completed Date:  2007-10-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8703941     Medline TA:  Ann Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  321-7     Citation Subset:  IM    
Division of Vascular Surgery, Department of Surgery, William Beaumont Hospital, Royal Oak, MI 48073, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Academic Medical Centers* / statistics & numerical data
Aged, 80 and over
Carotid Artery Diseases / epidemiology,  surgery
Carotid Artery, Common / surgery
Community Health Centers* / statistics & numerical data
Coronary Artery Disease / epidemiology
Endarterectomy, Carotid*
Endpoint Determination
Michigan / epidemiology
Middle Aged
Myocardial Infarction / epidemiology,  etiology
Nervous System Diseases / epidemiology,  etiology
Postoperative Complications / epidemiology,  etiology
Predictive Value of Tests
Research Design
Retrospective Studies
Risk Factors
Survival Analysis
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Technical limitations of carotid filter embolic protection devices.
Next Document:  Tyrosine hydroxylase positive neurons and their contacts with vasoactive intestinal polypeptide-cont...