| Contemporary antiviral drug regimens for the prevention and treatment of orolabial and anogenital herpes simplex virus infection in the normal host: Four approved indications and 13 off-label uses. | |
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MedLine Citation:
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PMID: 18159421 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Herpes simplex virus (HSV) orolabial and anogenital infection causes substantial and recurring disease in healthy individuals due directly to infection of these sites and, indirectly, due to its complications. These complications include eczema herpeticum plus erythema multiforme and neonatal HSV infection, respectively. Four drugs: acyclovir, famciclovir, valacyclovir and penciclovir, are currently licensed by the Therapeutics Products Directorate of Health Canada for the management of HSV infections. Although these drugs are only approved for four orolabial and anogenital infections in healthy persons, their efficacy and safety for 13 other related uses in this population have been demonstrated in controlled clinical trials, so called off-label uses. In this review, the evidence supporting these 17 uses, the drugs and regimens evaluated, and their current costs, are described. |
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Authors:
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Fred Y Aoki |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses Volume: 14 ISSN: 1180-2332 ISO Abbreviation: Can J Infect Dis Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2007-12-26 Completed Date: 2011-07-14 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 9425856 Medline TA: Can J Infect Dis Country: Canada |
Other Details:
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Languages: eng Pagination: 17-27 Citation Subset: - |
Affiliation:
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Departments of Medicine, Medical Microbiology, Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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