| Contemporary indications and therapeutic implications for digoxin use. | |
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MedLine Citation:
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PMID: 20224322 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Heart failure (HF) is a leading cause of morbidity and mortality. Appropriate medical therapy using angiotensin converting enzyme inhibitors and beta-blockers improves outcomes in HF, whereas the role of digoxin is still not clearly defined. Digoxin is currently recommended for patients with HF who are symptomatic despite standard therapy and for controlling the ventricular rate in atrial fibrillation. Digoxin is a time-tested drug that accounts for 20 million drug prescriptions annually in the United States. It has favorable hemodynamic effects for patients with HF and atrial tachyarrhythmias. We conducted a systematic literature search for the current indications for digoxin. Despite extensive research and safety data, the literature suggests that digoxin is underused in clinical settings. Citing the literature where available, our review highlights the various clinical settings where digoxin is indicated. Despite difficulties with designing prospective studies in acute HF settings and lack of outcomes data, we believe that digoxin will continue to serve an important role in optimizing care in certain acute and chronic cardiac conditions. |
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Authors:
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Mayank K Mittal; Priya Chockalingam; Anand Chockalingam |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of therapeutics Volume: 18 ISSN: 1536-3686 ISO Abbreviation: Am J Ther Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9441347 Medline TA: Am J Ther Country: United States |
Other Details:
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Languages: eng Pagination: 280-7 Citation Subset: IM |
Affiliation:
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1Division of Cardiovascular Medicine, Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO; 2Department of Cardiology and Pediatric Cardiology, Academic Medical Centre, Amsterdam, The Netherlands; and 3Cardiology Section, Harry S. Truman VA Medical Center, Columbia, MO. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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