Document Detail


Contemporaneous administration of digitalis and dilazep to subjects with heart failure of ischemic etiology.
MedLine Citation:
PMID:  6885209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this trial was to determine whether the digitalis-dilazep combination interferes with the inotropic effects of digitalis or produces significant cardiovascular modifications. Twenty patients suffering from heart failure of ischemic or ischemic plus valvular etiologies, undergoing digitalis treatment for at least 3 weeks, were administered dilazep (300 mg/day). Systolic, diastolic blood pressures and heart rate, supine and standing, QS2I, LVETI, PEPI, PEP/LVET, triple product, and percentage diastole were recorded. The controls were undertaken at entry, after the digitalis + dilazep association, and after 1 month of digitalis alone when dilazep was ceased. None of the parameters assessed were modified as a result of dilazep treatment. Since systolic time intervals and the PEP/LVET ratio remained unaltered and equal to the values recorded during digitalis alone, it is concluded that dilazep does not interfere with the inotropic action of digitalis.
Authors:
C Pasotti; P Gandolfi; L Ottolenghi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology, therapy, and toxicology     Volume:  21     ISSN:  0174-4879     ISO Abbreviation:  Int J Clin Pharmacol Ther Toxicol     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-10-28     Completed Date:  1983-10-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8003415     Medline TA:  Int J Clin Pharmacol Ther Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  370-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Azepines / administration & dosage*
Blood Pressure / drug effects
Coronary Disease / drug therapy*
Digitalis Glycosides / administration & dosage*
Dilazep / administration & dosage*
Drug Interactions
Drug Therapy, Combination
Female
Heart Rate / drug effects
Humans
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Azepines; 0/Digitalis Glycosides; 35898-87-4/Dilazep

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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