| Contamination of preservation fluid in kidney transplantation: single-center analysis. | |
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MedLine Citation:
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PMID: 20534219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Contamination of preservation fluid is common, with a reported incidence of 2.2% to 28.0%, and may be a major cause of early morbidity after transplantation. Herein, we report our experience with routine examination of preservation fluid collected just before implantation, focusing on the rate of contamination and the clinical consequences to recipients. MATERIALS AND METHODS: We analyzed 62 samples of preservation fluid for microbial and fungal contamination. RESULTS: Twenty-four samples (38.7%) were contaminated with at least 1 organism. Bacterial contamination alone was observed in 18 samples; all patients received prophylactic treatment with intravenous piperacillin/tazobactam, 4.5 g/d for 10 days, without clinical sequelae. Six samples were contaminated with Candida species; all patients received prophylactic treatment with fluconazole, 100 mg/d for 3 months. One patient developed reversible acute renal failure due to ureteral obstruction by fungus balls at 30 days after transplantation. CONCLUSION: Contamination of preservation fluid occurs frequently after kidney transplantation. Bacterial contamination evolved without symptoms in most patients treated with prophylactic antibiotic therapy. Fungal contamination may be potentially life-threatening. However, graft nephrectomy is not mandatory if the involved Candida species is identified correctly and appropriate antifungal therapy is rapidly prescribed. |
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Authors:
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M Veroux; D Corona; V Scriffignano; P Caglià; M Gagliano; G Giuffrida; F Gona; A Sciacca; A Giaquinta; S Oliveri; N Sinagra; T Tallarita; D Zerbo; M Sorbello; L Parrinello; P Veroux |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Transplantation proceedings Volume: 42 ISSN: 1873-2623 ISO Abbreviation: Transplant. Proc. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
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Languages: eng Pagination: 1043-5 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Surgery, Vascular Surgery and Organ Transplant Unit, University Hospital of Catania, Catania, Italy. veroux@unict.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal
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therapeutic use Antifungal Agents / therapeutic use Antilymphocyte Serum / therapeutic use Bacteria / isolation & purification* Candida / isolation & purification* Drug Contamination / statistics & numerical data* Female Fluconazole / therapeutic use Humans Immunosuppressive Agents / therapeutic use Kidney Transplantation / adverse effects, standards* Male Middle Aged Organ Preservation Solutions / adverse effects, standards* Recombinant Fusion Proteins / therapeutic use Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antifungal Agents; 0/Antilymphocyte Serum; 0/Immunosuppressive Agents; 0/Organ Preservation Solutions; 0/Recombinant Fusion Proteins; 0/basiliximab; 86386-73-4/Fluconazole |
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