| Contamination of 0.2-micrometer infusion filters by N,N-dimethylacrylamide. | |
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MedLine Citation:
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PMID: 19682842 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Infusion filters, 0.2 mum, are commonly used in intensive care units as in-line filters to minimize particle and microbiological burden on patients. These filters usually contain either a positively charged or an uncharged membrane. The aim of the present study was to identify and to quantify an additive causing an unexpected maximum at 234.5 nm in the ultraviolet spectrum of a filtered drug solution using a filter. MATERIALS AND METHODS: For identification and quantification of the substance, water for injection was used as eluent. Measurements were done by mass spectrometry and ultraviolet spectroscopy. RESULTS: The unexpected additive in the filter was found to be N,N-dimethylacrylamide. The eluate of 2 filter batches had a mean N,N-dimethylacrylamide concentration of 3.9 and 2.5 microg/mL, respectively. Further investigations showed that after infusion breaks of different duration, the N,N-dimethylacrylamide concentration at the beginning of the next infusion cycle reaches a higher level than that at the end of the preceding infusion cycle. CONCLUSIONS: The type of filter examined in this study is primarily used in premature infants, newborns, and infants. These patients are vulnerable to neurotoxic substances having a long-term effect. Therefore, N,N-dimethylacrylamide should be completely removed from the final filter product. |
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Authors:
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Joanna Gasch; Reinhard Oertel; Claudia S Leopold; Holger Knoth |
Publication Detail:
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Type: Journal Article Date: 2009-08-13 |
Journal Detail:
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Title: Journal of critical care Volume: 25 ISSN: 1557-8615 ISO Abbreviation: J Crit Care Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-04-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610642 Medline TA: J Crit Care Country: United States |
Other Details:
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Languages: eng Pagination: 172.e9-14 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Klinik-Apotheke, Universit?tsklinikum Carl Gustav Carus der Technischen Universit?t Dresden, 01307 Dresden, Germany. joanna@hw-arts.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acrylamides
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analysis* Digoxin Equipment Contamination* Filtration / instrumentation* Humans Intensive Care Units Mass Spectrometry Membranes, Artificial Particle Size Spectrophotometry, Ultraviolet |
| Chemical | |
Reg. No./Substance:
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0/Acrylamides; 0/Membranes, Artificial; 20830-75-5/Digoxin; 2680-03-7/N,N-dimethylacrylamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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