Document Detail

Contacts between mast cells and dendritic cells in the human skin.
MedLine Citation:
PMID:  21072986     Owner:  NLM     Status:  MEDLINE    
Langerhans cells are a dendritic cell type characteristic of the epidermis. Since mast cells secrete molecules potentially influent on dendritic cell differentiation, we have addressed the degree of proximity between these two cell types in biopsies of skin diseases characterized by massive influx of dendritic cell precursors. By fluorescence microscopy, avidin labeled mast cells were found in contact with CD1a+ dendritic cells. By electron microscopy, contacts between mast cells and blunty dendritic cells were found in areas corresponding to those where CD1a+ cells were localized by immunohistochemistry. We propose that mast cells can induce the differentiation of precursors into Langerhans cells through both the release of short range acting soluble factors and contact-mediating plasma membrane molecules.
Stefano Bacci; Nicola Pimpinelli; Paolo Romagnoli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia     Volume:  115     ISSN:  1122-6714     ISO Abbreviation:  Ital J Anat Embryol     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-15     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612303     Medline TA:  Ital J Anat Embryol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  25-30     Citation Subset:  IM    
Department of Anatomy, Histology and Forensic Medicine, Section "E. Allara", University of Florence, Italy.
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MeSH Terms
Cell Communication / physiology*
Cell Differentiation / physiology
Cytokines / secretion
Dermatitis / immunology,  metabolism,  pathology
Fluorescent Antibody Technique / methods
Langerhans Cells / physiology*,  ultrastructure
Mast Cells / cytology*,  physiology,  ultrastructure
Microscopy, Electron, Transmission / methods
Microscopy, Fluorescence / methods
Middle Aged
Skin / cytology*,  ultrastructure
Stem Cells / cytology,  physiology,  ultrastructure
Young Adult
Reg. No./Substance:

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