Document Detail

Contact sensitivity to nonoxynols as a cause of intolerance to antiseptic preparations.
MedLine Citation:
PMID:  2553785     Owner:  NLM     Status:  MEDLINE    
Twelve cases of allergic contact dermatitis caused by antiseptic preparations are presented. The reactions resulted not from the active principles but rather from nonoxynols used in the offending substances as nonionic surface-active agents. Nonoxynols are ethoxylated alkyl phenols or nonylphenylethers that conform in general to the formula C9H19C6H4(OCH2CH2)nOH. They have emulsifying, wetting, foaming, and solubilizing properties and are used in a large number of industrial, household, agricultural, cosmetic, and pharmaceutical products. They also are used as spermicides. There are very few reports in the literature of skin problems caused by nonoxynols.
A Dooms-Goossens; H Deveylder; A G de Alam; J M Lachapelle; D Tennstedt; H Degreef
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  21     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-12-18     Completed Date:  1989-12-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  723-7     Citation Subset:  IM    
Department of Medical Research (Dermatology), University Hospital, Katholieke Universiteit Leuven, Belgium.
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MeSH Terms
Anti-Infective Agents, Local*
Drug Hypersensitivity / etiology*
Middle Aged
Patch Tests
Polyethylene Glycols / adverse effects*
Surface-Active Agents / adverse effects*
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Polyethylene Glycols; 0/Surface-Active Agents; 26027-38-3/Nonoxynol

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