| Contact hypersensitivity: Animal tests. | |
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MedLine Citation:
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PMID: 20693056 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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After reviewing general aspects and the historical development of predictive animal skin sensitization tests, the recommended tests of the OECD and EC are discussed. Background information is given on the changes that have occurred during the last 2 yr. Although many factors are known to influence induction and elicitation of contact allergy in animals, the discussion is focused on the choice of induction concentration and the vehicle. Differences in general screening strategies between Europe and the USA are considered. The paper concludes with a discussion about the importance of in-house validation of the methods used for proper prediction of the sensitizing potential of chemicals and with remarks on predictive in vitro tests. |
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Authors:
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T Maurer; A Arthur; P Bentley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Toxicology in vitro : an international journal published in association with BIBRA Volume: 8 ISSN: 0887-2333 ISO Abbreviation: Toxicol In Vitro Publication Date: 1994 Oct |
Date Detail:
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Created Date: 2010-08-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8712158 Medline TA: Toxicol In Vitro Country: England |
Other Details:
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Languages: eng Pagination: 971-4 Citation Subset: - |
Affiliation:
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Ciba-Geigy Ltd, Pharmaceuticals Division, Preclinical Safety, CH-4002 Basel, Switzerland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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