Document Detail

Contact allergy to gold sodium thiosulfate.
MedLine Citation:
PMID:  7774184     Owner:  NLM     Status:  MEDLINE    
278 consecutive patients with suspected contact dermatitis were patch tested with the European standard series and gold sodium thiosulfate (0.5% pet.): 13 patients (4.6%) had a positive allergic response to gold sodium thiosulfate (GST). All of these patients were female, with a mean age of 37 years. The most frequent site of eczema in these patients was the head and neck (62%). A seborrhoeic distribution of eczema was common. 46% had involvement of the limbs, 15% had a perianal or perivulval rash. The mean duration of eczema in this group of patients was 15.8 months. 54% of patients allergic to gold were also allergic to nickel. Biopsy of positive patch test reactions to GST were consistent with allergic contact dermatitis.
K E McKenna; O Dolan; M Y Walsh; D Burrows
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Contact dermatitis     Volume:  32     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-07-07     Completed Date:  1995-07-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  143-6     Citation Subset:  IM; X    
Department of Dermatology, Royal Victoria Hospitals Trust, Belfast, Northern Ireland, UK.
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MeSH Terms
Anus Diseases / etiology
CD4-Positive T-Lymphocytes / pathology
CD8-Positive T-Lymphocytes / pathology
Dermatitis, Allergic Contact / etiology*,  immunology,  pathology
Eczema / etiology
Gold Alloys / adverse effects
Gold Sodium Thiosulfate / adverse effects*
HLA-DP Antigens / analysis
HLA-DQ Antigens / analysis
HLA-DR Antigens / analysis
Langerhans Cells / pathology
Middle Aged
Nickel / adverse effects
Patch Tests
T-Lymphocytes / pathology
Vulvar Diseases / etiology
Reg. No./Substance:
0/Gold Alloys; 0/HLA-DP Antigens; 0/HLA-DQ Antigens; 0/HLA-DR Antigens; 15283-45-1/Gold Sodium Thiosulfate; 7440-02-0/Nickel; 7786-81-4/nickel sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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