| Contact urticaria with systemic symptoms due to hexylene glycol in a topical corticosteroid: case report and review of hypersensitivity to glycols. | |
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MedLine Citation:
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PMID: 20185893 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a case of severe contact urticaria with systemic involvement resembling an anaphylactic reaction, following the application of a topical corticosteroid. This was caused by hexylene glycol, an excipient in the formulation. Glycols are widely used in cosmetics, foods and topical and systemic drugs. In particular, glycols are present in many topical drugs used by dermatologists. To our knowledge, this is the first case in the literature of a potentially life-threatening immediate-type reaction in the context of a contact urticaria syndrome due to hexylene glycol. The classification of contact urticaria syndrome and the allergenic potential of glycols are reviewed. Dermatologists should be aware of the contact urticaria syndrome and of the increasing use of glycols in topical drug formulation in order to identify possible adverse reactions. |
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Authors:
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D Spoerl; K Scherer; A J Bircher |
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Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2010-02-25 |
Journal Detail:
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Title: Dermatology (Basel, Switzerland) Volume: 220 ISSN: 1421-9832 ISO Abbreviation: Dermatology (Basel) Publication Date: 2010 |
Date Detail:
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Created Date: 2010-04-28 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203244 Medline TA: Dermatology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 238-42 Citation Subset: IM |
Copyright Information:
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2010 S. Karger AG, Basel. |
Affiliation:
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Allergy Unit, Department of Dermatology, University Hospital Basel, Basel, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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administration & dosage Adult Anaphylaxis / drug therapy, etiology*, pathology Dermatitis, Allergic Contact / drug therapy, etiology*, pathology Drug Hypersensitivity / drug therapy, etiology*, pathology Excipients / administration & dosage, adverse effects* Glycols / administration & dosage, adverse effects* Histamine Antagonists / therapeutic use Humans Male Ointments Urticaria / drug therapy, etiology*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Excipients; 0/Glycols; 0/Histamine Antagonists; 0/Ointments; 107-41-5/hexylene glycol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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