| Consumption of omega-3 fatty acids is not associated with a reduction in carotid atherosclerosis: the Genetics of Coronary Artery Disease in Alaska Natives study. | |
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MedLine Citation:
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PMID: 18054937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study was designed to evaluate the relation between omega-3 fatty acid (FA) consumption and atherosclerosis. BACKGROUND: The hypothesis that omega-3 FAs protect against atherosclerosis has not been tested with objective measures of atherosclerosis. METHODS: A population-based sample of 1131 Alaskan Eskimos of age >or=18 underwent ultrasound assessment of carotid atherosclerosis. Those of age >35 (N=686) were included in the analysis. Diet was assessed by a food frequency questionnaire. Intimal-medial thickness (IMT) of the far wall of the distal common carotid arteries and plaque score (number of segments containing plaque) were assessed. RESULTS: Mean consumption of total omega-3 FAs was 4.76 g/day in those without and 5.07 g/day in those with plaque. In models adjusting for relevant risk factors, presence and extent of plaque were unrelated to intake of C20-22 omega-3 FAs or total omega-3 FAs. In contrast, the odds of plaque rose significantly with quartiles of palmitic (p=0.02) and stearic acid intake (p=0.04). The extent of plaque (or plaque score) was also associated with a higher percentage intake of palmitic acid (p=0.01). IMT was negatively associated with grams of C20-22 omega-3 FAs (p=0.05), total omega-3 (p=0.05), palmitate (p=0.03), and stearate (p=0.03) consumed. CONCLUSIONS: Dietary intake of omega-3 FAs in a moderate-to-high range does not appear to be associated with reduced plaque, but is negatively associated with IMT. The presence and extent of carotid atherosclerosis among Eskimos is higher with increasing consumption of saturated FAs. |
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Authors:
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Sven O E Ebbesson; Mary J Roman; Richard B Devereux; David Kaufman; Richard R Fabsitz; Jean W Maccluer; Bennett Dyke; Sandra Laston; Charlotte R Wenger; Anthony G Comuzzie; Terry Romenesko; Lars O E Ebbesson; Elizabeth D Nobmann; Barbara V Howard |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2007-12-04 |
Journal Detail:
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Title: Atherosclerosis Volume: 199 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-28 Completed Date: 2008-11-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 346-53 Citation Subset: IM |
Affiliation:
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Norton Sound Health Corporation, Nome, AK 99762, United States. ffsoe@uaf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Alaska Carotid Artery Diseases / ethnology, genetics*, metabolism* Carotid Artery, Common / pathology Cohort Studies Diet Fatty Acids, Omega-3 / metabolism* Female Humans Inuits Male Middle Aged Questionnaires Tunica Intima / pathology Tunica Media / pathology |
| Grant Support | |
ID/Acronym/Agency:
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M10RR0047-34/RR/NCRR NIH HHS; R01-HL64244/HL/NHLBI NIH HHS; U01 HL082458/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3 |
| Comments/Corrections | |
Comment In:
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Atherosclerosis. 2008 Aug;199(2):451-3; author reply 454
[PMID:
18378242
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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