Document Detail

Consumption of omega-3 fatty acids is not associated with a reduction in carotid atherosclerosis: the Genetics of Coronary Artery Disease in Alaska Natives study.
MedLine Citation:
PMID:  18054937     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study was designed to evaluate the relation between omega-3 fatty acid (FA) consumption and atherosclerosis. BACKGROUND: The hypothesis that omega-3 FAs protect against atherosclerosis has not been tested with objective measures of atherosclerosis. METHODS: A population-based sample of 1131 Alaskan Eskimos of age >or=18 underwent ultrasound assessment of carotid atherosclerosis. Those of age >35 (N=686) were included in the analysis. Diet was assessed by a food frequency questionnaire. Intimal-medial thickness (IMT) of the far wall of the distal common carotid arteries and plaque score (number of segments containing plaque) were assessed. RESULTS: Mean consumption of total omega-3 FAs was 4.76 g/day in those without and 5.07 g/day in those with plaque. In models adjusting for relevant risk factors, presence and extent of plaque were unrelated to intake of C20-22 omega-3 FAs or total omega-3 FAs. In contrast, the odds of plaque rose significantly with quartiles of palmitic (p=0.02) and stearic acid intake (p=0.04). The extent of plaque (or plaque score) was also associated with a higher percentage intake of palmitic acid (p=0.01). IMT was negatively associated with grams of C20-22 omega-3 FAs (p=0.05), total omega-3 (p=0.05), palmitate (p=0.03), and stearate (p=0.03) consumed. CONCLUSIONS: Dietary intake of omega-3 FAs in a moderate-to-high range does not appear to be associated with reduced plaque, but is negatively associated with IMT. The presence and extent of carotid atherosclerosis among Eskimos is higher with increasing consumption of saturated FAs.
Sven O E Ebbesson; Mary J Roman; Richard B Devereux; David Kaufman; Richard R Fabsitz; Jean W Maccluer; Bennett Dyke; Sandra Laston; Charlotte R Wenger; Anthony G Comuzzie; Terry Romenesko; Lars O E Ebbesson; Elizabeth D Nobmann; Barbara V Howard
Related Documents :
8877657 - Toothbrushing force in relation to plaque removal.
6586127 - An investigation of the effects of maltose and sucrose in the diet on the microbiology ...
15759747 - The heatox project.
3560247 - Use of interstitial hyperthermia to produce homogeneous heat distribution patterns.
21652267 - Which food patterns are predictors of obesity in tehranian adults?
15720697 - Winter photosynthesis by saplings of evergreen broad-leaved trees in a deciduous temper...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-12-04
Journal Detail:
Title:  Atherosclerosis     Volume:  199     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-28     Completed Date:  2008-11-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  346-53     Citation Subset:  IM    
Norton Sound Health Corporation, Nome, AK 99762, United States.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Carotid Artery Diseases / ethnology,  genetics*,  metabolism*
Carotid Artery, Common / pathology
Cohort Studies
Fatty Acids, Omega-3 / metabolism*
Middle Aged
Tunica Intima / pathology
Tunica Media / pathology
Grant Support
Reg. No./Substance:
0/Fatty Acids, Omega-3
Comment In:
Atherosclerosis. 2008 Aug;199(2):451-3; author reply 454   [PMID:  18378242 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Molecular epidemiology of Cryptosporidium in humans and cattle in The Netherlands.
Next Document:  Endothelial cells are protected against phagocyte-transmitted Chlamydophila pneumoniae infections by...