Document Detail

Consumption of folate-related nutrients and metabolism of arsenic in Bangladesh.
MedLine Citation:
PMID:  17490975     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Inorganic arsenic (InAs) is metabolized to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA), and this methylation facilitates urinary arsenic excretion. Previous studies suggest that persons with more complete methylation, characterized as greater proportions of DMA and lesser proportions of MMA and InAs in urine, have a lower risk of adverse arsenic-related health outcomes. OBJECTIVE: The purpose of this study was to examine whether the capacity to methylate arsenic differs by nutrient intake. DESIGN: Participants were 1016 Bangladeshi adults exposed to arsenic in drinking water. Nutrient intake was assessed with a validated food-frequency questionnaire. Multivariate regression analyses were used to examine associations of nutrients with urinary arsenic metabolite profiles. RESULTS: In multivariate analyses, higher intakes of cysteine, methionine, calcium, protein, and vitamin B-12 were associated with lower percentages of InAs and higher ratios of MMA to InAs in urine. Higher intakes of niacin (beta=0.22, P=0.02) and choline (beta=0.10, P=0.02) were associated with higher DMA-to-MMA ratios, after adjustment for age, sex, smoking, total urinary arsenic, and total energy intake. CONCLUSIONS: Findings from the current study show the influence of multiple nutrients on arsenic methylation. In particular, this study highlights the potential importance of dietary intakes of cysteine, methionine, niacin, vitamin B-12, and choline on health effects of arsenic by modulating its metabolism.
Julia E Heck; Mary V Gamble; Yu Chen; Joseph H Graziano; Vesna Slavkovich; Faruque Parvez; John A Baron; Geoffrey R Howe; Habibul Ahsan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  85     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-10     Completed Date:  2007-06-14     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1367-74     Citation Subset:  AIM; IM    
Department of Epidemiology, Mailman School of Public Health and Institute for Social and Economic Research and Policy, Columbia University, New York, NY, USA.
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MeSH Terms
Arsenic / metabolism*,  urine
Arsenicals / metabolism,  urine
Cacodylic Acid / metabolism,  urine
Choline / metabolism
Cysteine / metabolism
Dietary Proteins / metabolism*,  urine
Dose-Response Relationship, Drug
Environmental Exposure
Folic Acid / metabolism*
Methionine / metabolism
Methylation / drug effects*
Middle Aged
Multivariate Analysis
Niacin / metabolism
Vitamin B 12 / metabolism
Vitamin B Complex / metabolism
Water Pollutants, Chemical / metabolism*,  urine
Grant Support
Reg. No./Substance:
0/Arsenicals; 0/Dietary Proteins; 0/Water Pollutants, Chemical; 12001-76-2/Vitamin B Complex; 124-58-3/monomethylarsonic acid; 52-90-4/Cysteine; 59-30-3/Folic Acid; 59-67-6/Niacin; 62-49-7/Choline; 63-68-3/Methionine; 68-19-9/Vitamin B 12; 7440-38-2/Arsenic; 75-60-5/Cacodylic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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