Document Detail


Consumption of different soymilk formulations differentially affects the gut microbiomes of overweight and obese men.
MedLine Citation:
PMID:  22895080     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of consuming foods on the intestinal microbiome of obese individuals remain unclear. The objective of this study was to compare the effects of consuming low glycinin soymilk (LGS, 49.5% β-conglycinin/6% glycinin), conventional soymilk (S, 26.5% β-conglycinin/38.7% glycinin) or bovine milk (M, 0% β-conglycinin/0% glycinin) on the intestinal microbiome in overweight and obese men. In a randomized double-blind study, participants (64 men, BMI > 25, 20-45 y old), organized in three groups, consumed 500 mL of LGS, S or M daily for 3 mo. Three fecal samples were collected before (baseline) and after 3 mo of consumption. Dietary energy and macronutrient intake were monitored monthly and remained constant throughout the study (p > 0.05). Microbial composition was analyzed with qPCR and bTEFAP. Within groups, qPCR analysis showed that the total bacteria increased in all treatments over time (p < 0.001). Bacteroides-Prevotella (p = 0.001) and Lactobacillus (p < 0.001) increased in LGS and M, respectively. Bifidobacterium was significantly reduced in LGS (p = 0.003) and S (p < 0.001). Bacterial diversity decreased for LGS, S and M (p = 0.004, 0.005, 0.001; respectively). Unweighted UniFrac analysis revealed that the microbial communities were more similar within than between individuals. The Firmicutes to Bacteroidetes ratio decreased in both LGS and S groups and remained relatively unchanged in the M group (Time p = 0.012; Interaction p = 0.059). Indicator analysis revealed several genera that were indicative of each treatment including Lactobacillus and Prevotella. Consumption of the three beverages differentially altered the microbiota in overweight and obese men including a potentially beneficial alteration of the Firmicutes to Bacteroidetes ratio in both soymilk groups.
Authors:
Dina Fernandez-Raudales; Jennifer L Hoeflinger; Neal A Bringe; Stephen B Cox; Scot E Dowd; Michael J Miller; Elvira Gonzalez de Mejia
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-08-16
Journal Detail:
Title:  Gut microbes     Volume:  3     ISSN:  1949-0984     ISO Abbreviation:  Gut Microbes     Publication Date:    2012 Nov-Dec
Date Detail:
Created Date:  2012-11-02     Completed Date:  2013-04-09     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  101495343     Medline TA:  Gut Microbes     Country:  United States    
Other Details:
Languages:  eng     Pagination:  490-500     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Biota*
DNA Fingerprinting / methods
Diet / methods*
Double-Blind Method
Feces / microbiology*
Humans
Male
Middle Aged
Milk / metabolism
Obesity / therapy*
Soy Milk / administration & dosage*
Young Adult
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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