| Consumption of a legume-enriched, low-glycemic index diet is associated with biomarkers of insulin resistance and inflammation among men at risk for colorectal cancer. | |
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MedLine Citation:
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PMID: 19889807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Legume Inflammation Feeding Experiment is, to our knowledge, the first randomized crossover feeding trial testing the effects of a legume-enriched, low-glycemic index (GI) diet among men characterized for colorectal adenomas and insulin resistance (IR) status. This study was designed to test the effects of a legume-enriched diet compared with a healthy American (HA) diet under weight-stable conditions. The primary objective was to assess effects on C-reactive protein (CRP) and C-peptide levels. The secondary objective was to assess changes by IR status or history of adenomas. A total of 64 men who completed a colonoscopy within the previous 2 y consumed 2 diets in random order each for 4 wk separated by a washout period. The diets were a legume-enriched (250 g/d), low-GI (GI 38) diet and a high-GI (GI 69) HA diet. We measured fasting glucose, insulin, C-peptide, CRP, and soluble tumor necrosis factor-alpha receptors I and II (sTNFRI/II) at the beginning and end of the diet periods. Participants who consumed both the legume and HA diets had favorably improved CRP (-20.2 and -18.3%) and sTNFRI (-3.7 and -4.4%) concentrations, respectively. The sTNFRII concentrations declined marginally during the legume diet period (-3.8%; P = 0.060) and significantly during the HA diet period (-5.1%; P < 0.001). Fasting glucose increased significantly during both the legume (+1.8%) and HA (-2.2%) diet periods. Only the changes in glucose differed between the diet periods. Serum C-peptide and plasma insulin levels did not change in participants consuming either diet. Healthful dietary changes can improve biomarkers of IR and inflammation. |
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Authors:
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Terryl J Hartman; Paul S Albert; Zhiying Zhang; Deborah Bagshaw; Penny M Kris-Etherton; Jan Ulbrecht; Carla K Miller; Gerd Bobe; Nancy H Colburn; Elaine Lanza |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2009-11-04 |
Journal Detail:
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Title: The Journal of nutrition Volume: 140 ISSN: 1541-6100 ISO Abbreviation: J. Nutr. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-21 Completed Date: 2010-01-21 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 60-7 Citation Subset: IM |
Affiliation:
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Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16870, USA. tjh9@psu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers* Colorectal Neoplasms / metabolism, prevention & control* Cross-Over Studies Diet* Fabaceae* Glycemic Index / physiology* Humans Inflammation / blood* Insulin Resistance* Male Middle Aged Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR 10732/RR/NCRR NIH HHS; M01 RR010732-128535/RR/NCRR NIH HHS; M01 RR010732-136641/RR/NCRR NIH HHS; M01 RR010732-145061/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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