Document Detail


The consumption of food products from linseed-fed animals maintains erythrocyte omega-3 fatty acids in obese humans.
MedLine Citation:
PMID:  20012223     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Based on mechanistic and epidemiological data, we raise the question of the relationship between qualitative dietary polyunsaturated fatty acids (PUFA) changes and increase in obesity. In this double-blind trial, we studied the effects on 160 overweight volunteers (body mass index, BMI >30) of a 90 days experimental diet rich principally in animal fat with a low PUFA/saturated fatty acid (SFA) ratio but a low n-6/n-3 ratio, using animal products obtained from linseed-fed animals. The control diet provided less animal fat, a higher PUFA/SFA ratio and a higher n-6/n-3 ratio. Both diets excluded seafood. In the experimental group, we observed a significant increase in red blood cell (RBC) alpha-linolenic acid content and a slight increase in EPA and DHA derivatives, while in the control group we observed a significant reduction in EPA and DHA content. Between groups now, the difference in the three n-3 fatty acids changes in RBC was significant. This demonstrates that plasma EPA and DHA levels can be maintained without fish if products from linseed-fed animals are used. During the diets, we noted a significant reduction in weight, BMI and hip circumference within both groups of volunteers. However, no significant difference was observed between the control group and the experimental group. Interestingly, 150 days after the end of the trial (i.e., day 240), we noted a significant weight gain in the control group, whereas no significant weight gain was observed in the experimental group. This was also observed for the BMI and hip circumference. Moreover, significant differences in BMI (P < 0.05) and weight (P = 0.05) appeared between the two groups, showing in both cases a smaller increase in the experimental group. During the 90 days trial, we did not observe any differences between groups in terms of total cholesterol, HDL cholesterol, LDL cholesterol or triglycerides, suggesting that the saturate content and the P/S ratio are not as important as the n-6 and n-3 fatty acid composition.
Authors:
Philippe Legrand; B Schmitt; J Mourot; D Catheline; G Chesneau; M Mireaux; N Kerhoas; P Weill
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2009-12-11
Journal Detail:
Title:  Lipids     Volume:  45     ISSN:  1558-9307     ISO Abbreviation:  Lipids     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  11-9     Citation Subset:  IM    
Affiliation:
Biochimie-Nutrition Humaine Agrocampus-INRA, Rennes, France. philippe.legrand@agrocampus-ouest.fr
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MeSH Terms
Descriptor/Qualifier:
Adult
Animal Feed*
Animals
Body Mass Index
Dietary Fats / administration & dosage*
Double-Blind Method
Erythrocytes / chemistry*
Fatty Acids, Omega-3 / blood*
Female
Flax
Hip / anatomy & histology
Humans
Male
Metabolic Syndrome X / blood*
Middle Aged
Obesity / blood*
alpha-Linolenic Acid / metabolism
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids, Omega-3; 463-40-1/alpha-Linolenic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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