Document Detail


Consumption of a DHA-containing functional food during pregnancy is associated with lower infant ponderal index and cord plasma insulin concentration.
MedLine Citation:
PMID:  21521543     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
DHA (22 : 6n-3) in pregnancy has previously been shown to benefit infant brain and retinal development. Fatty acid consumption during pregnancy may also have an impact on infant adipose tissue development. The objective of the present study was to assess the prenatal impact of a DHA-containing functional food (DHA-FF) on infant intra-uterine growth. This was a longitudinal, randomised, double-blinded, placebo-controlled trial. Pregnant women were assigned to consume a DHA-FF or placebo bar from 24 weeks' gestation until delivery. Blood samples were collected from mothers at baseline and delivery and from the umbilical cord at delivery. Plasma and erythrocyte fatty acids were analysed by GLC and plasma insulin concentrations were analysed using a commercially available ELISA kit. Infant birth weight and length were obtained at delivery and ponderal index (weight (g)/length (cm)3 × 100) was calculated. A total of forty-seven mothers completed the study. Infants of mothers consuming the DHA-FF during the last half of pregnancy had lower ponderal indices (β = 0.198, P < 0.05) and umbilical cord blood insulin concentrations (β = 0.743, P < 0.05) than infants of mothers consuming the placebo. Thus, DHA consumption during pregnancy may be advantageous with respect to infant body composition at birth and insulin sensitivity.
Authors:
Amber B Courville; Ofer Harel; Carol J Lammi-Keefe
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The British journal of nutrition     Volume:  106     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2012-07-27     Completed Date:  2012-08-06     Revised Date:  2012-11-28    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  208-12     Citation Subset:  IM    
Affiliation:
Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA.
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MeSH Terms
Descriptor/Qualifier:
Birth Weight / drug effects*
Body Composition / drug effects*
Body Height
Diet
Dietary Fats / pharmacology*
Docosahexaenoic Acids / pharmacology*
Double-Blind Method
Enzyme-Linked Immunosorbent Assay
Female
Fetal Blood
Fetal Development / drug effects*
Functional Food
Gestational Age
Humans
Infant, Newborn
Insulin / blood*
Longitudinal Studies
Male
Pregnancy
Prenatal Nutritional Physiological Phenomena*
Grant Support
ID/Acronym/Agency:
K01 MH087219/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Insulin; 25167-62-8/Docosahexaenoic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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