| Consumption of a DHA-containing functional food during pregnancy is associated with lower infant ponderal index and cord plasma insulin concentration. | |
| | |
MedLine Citation:
|
PMID: 21521543 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
DHA (22 : 6n-3) in pregnancy has previously been shown to benefit infant brain and retinal development. Fatty acid consumption during pregnancy may also have an impact on infant adipose tissue development. The objective of the present study was to assess the prenatal impact of a DHA-containing functional food (DHA-FF) on infant intra-uterine growth. This was a longitudinal, randomised, double-blinded, placebo-controlled trial. Pregnant women were assigned to consume a DHA-FF or placebo bar from 24 weeks' gestation until delivery. Blood samples were collected from mothers at baseline and delivery and from the umbilical cord at delivery. Plasma and erythrocyte fatty acids were analysed by GLC and plasma insulin concentrations were analysed using a commercially available ELISA kit. Infant birth weight and length were obtained at delivery and ponderal index (weight (g)/length (cm)3 × 100) was calculated. A total of forty-seven mothers completed the study. Infants of mothers consuming the DHA-FF during the last half of pregnancy had lower ponderal indices (β = 0.198, P < 0.05) and umbilical cord blood insulin concentrations (β = 0.743, P < 0.05) than infants of mothers consuming the placebo. Thus, DHA consumption during pregnancy may be advantageous with respect to infant body composition at birth and insulin sensitivity. |
| | |
Authors:
|
Amber B Courville; Ofer Harel; Carol J Lammi-Keefe |
Related Documents
:
|
21042453 - Case report: congenital short bowel syndrome. 21324613 - Maternal vitamin b-12 and folate status during pregnancy and excessive infant crying. 21973113 - Personal growth in mothers: examination of the suitability of the posttraumatic growth ... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: The British journal of nutrition Volume: 106 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2012-07-27 Completed Date: 2012-08-06 Revised Date: 2012-11-28 |
Medline Journal Info:
|
Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
|
Languages: eng Pagination: 208-12 Citation Subset: IM |
Affiliation:
|
Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Birth Weight
/
drug effects* Body Composition / drug effects* Body Height Diet Dietary Fats / pharmacology* Docosahexaenoic Acids / pharmacology* Double-Blind Method Enzyme-Linked Immunosorbent Assay Female Fetal Blood Fetal Development / drug effects* Functional Food Gestational Age Humans Infant, Newborn Insulin / blood* Longitudinal Studies Male Pregnancy Prenatal Nutritional Physiological Phenomena* |
| Grant Support | |
ID/Acronym/Agency:
|
K01 MH087219/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Dietary Fats; 0/Insulin; 25167-62-8/Docosahexaenoic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Protein deficiency, but not zinc deficiency, reduces recovery of type 1 and type 2 muscle fibre diam...
Next Document: Umbilical venous-arterial plasma composition differences suggest differential incorporation of fatty...